2qh7

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[[Image:2qh7.jpg|left|200px]]
[[Image:2qh7.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qh7 |SIZE=350|CAPTION= <scene name='initialview01'>2qh7</scene>, resolution 1.500&Aring;
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The line below this paragraph, containing "STRUCTURE_2qh7", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= ZCD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2qh7| PDB=2qh7 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qh7 OCA], [http://www.ebi.ac.uk/pdbsum/2qh7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qh7 RCSB]</span>
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'''MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone'''
'''MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone'''
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[[Category: Wiley, S E.]]
[[Category: Wiley, S E.]]
[[Category: 2fe-2s protein]]
[[Category: 2fe-2s protein]]
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[[Category: metal binding protein]]
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[[Category: Metal binding protein]]
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[[Category: mitoneet]]
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[[Category: Mitoneet]]
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[[Category: outer mitochrodrial membrane protein]]
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[[Category: Outer mitochrodrial membrane protein]]
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[[Category: pioglitazone binding]]
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[[Category: Pioglitazone binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:57:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:49:19 2008''
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Revision as of 11:57, 4 May 2008

Image:2qh7.jpg

Template:STRUCTURE 2qh7

MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone


Overview

Iron-sulfur (Fe-S) proteins are key players in vital processes involving energy homeostasis and metabolism from the simplest to most complex organisms. We report a 1.5 A x-ray crystal structure of the first identified outer mitochondrial membrane Fe-S protein, mitoNEET. Two protomers intertwine to form a unique dimeric structure that constitutes a new fold to not only the approximately 650 reported Fe-S protein structures but also to all known proteins. We name this motif the NEET fold. The protomers form a two-domain structure: a beta-cap domain and a cluster-binding domain that coordinates two acid-labile 2Fe-2S clusters. Binding of pioglitazone, an insulin-sensitizing thiazolidinedione used in the treatment of type 2 diabetes, stabilizes the protein against 2Fe-2S cluster release. The biophysical properties of mitoNEET suggest that it may participate in a redox-sensitive signaling and/or in Fe-S cluster transfer.

About this Structure

2QH7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone., Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA, Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14342-7. Epub 2007 Aug 31. PMID:17766440 Page seeded by OCA on Sun May 4 14:57:55 2008

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