2qi2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2qi2.jpg|left|200px]]
[[Image:2qi2.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2qi2 |SIZE=350|CAPTION= <scene name='initialview01'>2qi2</scene>, resolution 2.90&Aring;
+
The line below this paragraph, containing "STRUCTURE_2qi2", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2qi2| PDB=2qi2 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qi2 OCA], [http://www.ebi.ac.uk/pdbsum/2qi2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qi2 RCSB]</span>
+
-
}}
+
'''Crystal structure of the Thermoplasma acidophilum Pelota protein'''
'''Crystal structure of the Thermoplasma acidophilum Pelota protein'''
Line 32: Line 29:
[[Category: Lee, H H.]]
[[Category: Lee, H H.]]
[[Category: Suh, S W.]]
[[Category: Suh, S W.]]
-
[[Category: cell cycle]]
+
[[Category: Cell cycle]]
-
[[Category: dom34]]
+
[[Category: Dom34]]
-
[[Category: pelota]]
+
[[Category: Pelota]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:00:06 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:49:35 2008''
+

Revision as of 12:00, 4 May 2008

Image:2qi2.jpg

Template:STRUCTURE 2qi2

Crystal structure of the Thermoplasma acidophilum Pelota protein


Overview

The yeast protein Dom34 is a key component of no-go decay, by which mRNAs with translational stalls are endonucleolytically cleaved and subsequently degraded. However, the identity of the endoribonuclease is unknown. Homologs of Dom34, called Pelota, are broadly conserved in eukaryotes and archaea. To gain insights into the structure and function of Dom34/Pelota, we have determined the structure of Pelota from Thermoplasma acidophilum (Ta Pelota) and investigated the ribonuclease activity of Dom34/Pelota. The structure of Ta Pelota is tripartite, and its domain 1 has the RNA-binding Sm fold. We have discovered that Ta Pelota has a ribonuclease activity and that its domain 1 is sufficient for the catalytic activity. We also demonstrate that domain 1 of Dom34 has an endoribonuclease activity against defined RNA substrates containing a stem loop, which supports a direct catalytic role of yeast Dom34 in no-go mRNA decay.

About this Structure

2QI2 is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Structural and functional insights into Dom34, a key component of no-go mRNA decay., Lee HH, Kim YS, Kim KH, Heo I, Kim SK, Kim O, Kim HK, Yoon JY, Kim HS, Kim do J, Lee SJ, Yoon HJ, Kim SJ, Lee BG, Song HK, Kim VN, Park CM, Suh SW, Mol Cell. 2007 Sep 21;27(6):938-50. PMID:17889667 Page seeded by OCA on Sun May 4 15:00:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qi2"
Personal tools