2qj3

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[[Image:2qj3.jpg|left|200px]]
[[Image:2qj3.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qj3 |SIZE=350|CAPTION= <scene name='initialview01'>2qj3</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2qj3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/[Acyl-carrier-protein]_S-malonyltransferase [Acyl-carrier-protein] S-malonyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.39 2.3.1.39] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= fabD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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-->
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|DOMAIN=
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{{STRUCTURE_2qj3| PDB=2qj3 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qj3 OCA], [http://www.ebi.ac.uk/pdbsum/2qj3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qj3 RCSB]</span>
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}}
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'''Mycobacterium tuberculosis FabD'''
'''Mycobacterium tuberculosis FabD'''
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: [Acyl-carrier-protein] S-malonyltransferase]]
 
[[Category: Besra, G S.]]
[[Category: Besra, G S.]]
[[Category: Brown, A K.]]
[[Category: Brown, A K.]]
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[[Category: Ghadbane, H.]]
[[Category: Ghadbane, H.]]
[[Category: Kremer, L.]]
[[Category: Kremer, L.]]
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[[Category: fatty acid synthase]]
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[[Category: Fatty acid synthase]]
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[[Category: malonyl-coa]]
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[[Category: Malonyl-coa]]
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[[Category: mycolic acid]]
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[[Category: Mycolic acid]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:02:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:49:53 2008''
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Revision as of 12:02, 4 May 2008

Image:2qj3.jpg

Template:STRUCTURE 2qj3

Mycobacterium tuberculosis FabD


Overview

Mycobacteria display a unique and unusual cell-wall architecture, central to which is the membrane-proximal mycolyl-arabinogalactan-peptidoglycan core (mAGP). The biosynthesis of mycolic acids, which form the outermost layer of the mAGP core, involves malonyl-CoA:acyl carrier protein transacylase (MCAT). This essential enzyme catalyses the transfer of malonyl from coenzyme A to acyl carrier protein AcpM, thus feeding these two-carbon units into the chain-elongation cycle of the type II fatty-acid synthase. The crystal structure of M. tuberculosis mtFabD, the mycobacterial MCAT, has been determined to 3.0 A resolution by multi-wavelength anomalous dispersion. Phasing was facilitated by Ni2+ ions bound to the 20-residue N-terminal affinity tag, which packed between the two independent copies of mtFabD.

About this Structure

2QJ3 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT)., Ghadbane H, Brown AK, Kremer L, Besra GS, Futterer K, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt, 10):831-5. Epub 2007 Sep 19. PMID:17909282 Page seeded by OCA on Sun May 4 15:02:38 2008

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OCA

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