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2qj3
From Proteopedia
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[[Image:2qj3.jpg|left|200px]] | [[Image:2qj3.jpg|left|200px]] | ||
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| - | | | + | {{STRUCTURE_2qj3| PDB=2qj3 | SCENE= }} |
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'''Mycobacterium tuberculosis FabD''' | '''Mycobacterium tuberculosis FabD''' | ||
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[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: [Acyl-carrier-protein] S-malonyltransferase]] | ||
[[Category: Besra, G S.]] | [[Category: Besra, G S.]] | ||
[[Category: Brown, A K.]] | [[Category: Brown, A K.]] | ||
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[[Category: Ghadbane, H.]] | [[Category: Ghadbane, H.]] | ||
[[Category: Kremer, L.]] | [[Category: Kremer, L.]] | ||
| - | [[Category: | + | [[Category: Fatty acid synthase]] |
| - | [[Category: | + | [[Category: Malonyl-coa]] |
| - | [[Category: | + | [[Category: Mycolic acid]] |
| - | [[Category: | + | [[Category: Transferase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:02:38 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 12:02, 4 May 2008
Mycobacterium tuberculosis FabD
Overview
Mycobacteria display a unique and unusual cell-wall architecture, central to which is the membrane-proximal mycolyl-arabinogalactan-peptidoglycan core (mAGP). The biosynthesis of mycolic acids, which form the outermost layer of the mAGP core, involves malonyl-CoA:acyl carrier protein transacylase (MCAT). This essential enzyme catalyses the transfer of malonyl from coenzyme A to acyl carrier protein AcpM, thus feeding these two-carbon units into the chain-elongation cycle of the type II fatty-acid synthase. The crystal structure of M. tuberculosis mtFabD, the mycobacterial MCAT, has been determined to 3.0 A resolution by multi-wavelength anomalous dispersion. Phasing was facilitated by Ni2+ ions bound to the 20-residue N-terminal affinity tag, which packed between the two independent copies of mtFabD.
About this Structure
2QJ3 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT)., Ghadbane H, Brown AK, Kremer L, Besra GS, Futterer K, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt, 10):831-5. Epub 2007 Sep 19. PMID:17909282 Page seeded by OCA on Sun May 4 15:02:38 2008
