2qjo

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[[Image:2qjo.jpg|left|200px]]
[[Image:2qjo.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qjo |SIZE=350|CAPTION= <scene name='initialview01'>2qjo</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2qjo", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+402'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+403'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+404'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+401'>AC4</scene>, <scene name='pdbsite=AC5:Apr+Binding+Site+For+Residue+A+501'>AC5</scene>, <scene name='pdbsite=AC6:Nad+Binding+Site+For+Residue+A+601'>AC6</scene>, <scene name='pdbsite=AC7:Pop+Binding+Site+For+Residue+A+701'>AC7</scene>, <scene name='pdbsite=AC8:Apr+Binding+Site+For+Residue+B+502'>AC8</scene>, <scene name='pdbsite=AC9:Nad+Binding+Site+For+Residue+B+602'>AC9</scene>, <scene name='pdbsite=BC1:Pop+Binding+Site+For+Residue+B+702'>BC1</scene>, <scene name='pdbsite=BC2:Apr+Binding+Site+For+Residue+C+503'>BC2</scene>, <scene name='pdbsite=BC3:Nad+Binding+Site+For+Residue+C+603'>BC3</scene> and <scene name='pdbsite=BC4:Pop+Binding+Site+For+Residue+C+703'>BC4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= slr0787 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1143 Synechocystis sp.])
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-->
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|DOMAIN=
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{{STRUCTURE_2qjo| PDB=2qjo | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjo OCA], [http://www.ebi.ac.uk/pdbsum/2qjo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qjo RCSB]</span>
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}}
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'''crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase (NadM) complexed with ADPRP and NAD from Synechocystis sp.'''
'''crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase (NadM) complexed with ADPRP and NAD from Synechocystis sp.'''
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[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: two individual domain]]
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[[Category: Two individual domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:04:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:50:00 2008''
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Revision as of 12:04, 4 May 2008

Image:2qjo.jpg

Template:STRUCTURE 2qjo

crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase (NadM) complexed with ADPRP and NAD from Synechocystis sp.


Overview

Bacterial NadM-Nudix is a bifunctional enzyme containing a nicotinamide mononucleotide (NMN) adenylyltransferase and an ADP-ribose (ADPR) pyrophosphatase domain. While most members of this enzyme family, such as that from a model cyanobacterium Synechocystis sp., are involved primarily in nicotinamide adenine dinucleotide (NAD) salvage/recycling pathways, its close homolog in a category-A biodefense pathogen, Francisella tularensis, likely plays a central role in a recently discovered novel pathway of NAD de novo synthesis. The crystal structures of NadM-Nudix from both species, including their complexes with various ligands and catalytic metal ions, revealed detailed configurations of the substrate binding and catalytic sites in both domains. The structure of the N-terminal NadM domain may be exploited for designing new antitularemia therapeutics. The ADPR binding site in the C-terminal Nudix domain is substantially different from that of Escherichia coli ADPR pyrophosphatase, and is more similar to human NUDT9. The latter observation provided new insights into the ligand binding mode of ADPR-gated Ca(2+) channel TRPM2.

About this Structure

2QJO is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism., Huang N, Sorci L, Zhang X, Brautigam CA, Li X, Raffaelli N, Magni G, Grishin NV, Osterman AL, Zhang H, Structure. 2008 Feb;16(2):196-209. PMID:18275811 Page seeded by OCA on Sun May 4 15:04:22 2008

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