2qmf

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[[Image:2qmf.jpg|left|200px]]
[[Image:2qmf.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qmf |SIZE=350|CAPTION= <scene name='initialview01'>2qmf</scene>, resolution 1.750&Aring;
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The line below this paragraph, containing "STRUCTURE_2qmf", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Cs9+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Cs9+Binding+Site+For+Residue+B+1'>AC2</scene>, <scene name='pdbsite=AC3:Tar+Binding+Site+For+Residue+A+2'>AC3</scene> and <scene name='pdbsite=AC4:Tar+Binding+Site+For+Residue+B+3'>AC4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CS9:N&#39;-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE'>CS9</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2qmf| PDB=2qmf | SCENE= }}
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|RELATEDENTRY=[[2qk5|2qk5]], [[2qkj|2qkj]], [[2qmd|2qmd]], [[2qmg|2qmg]], [[2qp8|2qp8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qmf OCA], [http://www.ebi.ac.uk/pdbsum/2qmf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qmf RCSB]</span>
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}}
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'''Structure of BACE Bound to SCH735310'''
'''Structure of BACE Bound to SCH735310'''
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[[Category: Iserloh, U.]]
[[Category: Iserloh, U.]]
[[Category: Strickland, C O.]]
[[Category: Strickland, C O.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: bace1]]
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[[Category: Bace1]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: zymogen]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:12:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:50:52 2008''
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Revision as of 12:12, 4 May 2008

Image:2qmf.jpg

Template:STRUCTURE 2qmf

Structure of BACE Bound to SCH735310


Overview

Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the most potent inhibitors synthesized to date.

About this Structure

2QMF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors., Iserloh U, Wu Y, Cumming JN, Pan J, Wang LY, Stamford AW, Kennedy ME, Kuvelkar R, Chen X, Parker EM, Strickland C, Voigt J, Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. Epub 2007 Nov 6. PMID:18023580 Page seeded by OCA on Sun May 4 15:12:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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