2qqs

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[[Image:2qqs.jpg|left|200px]]
[[Image:2qqs.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qqs |SIZE=350|CAPTION= <scene name='initialview01'>2qqs</scene>, resolution 2.82&Aring;
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The line below this paragraph, containing "STRUCTURE_2qqs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= JMJD2A, JHDM3A, JMJD2, KIAA0677 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2qqs| PDB=2qqs | SCENE= }}
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|RELATEDENTRY=[[2qqr|2QQR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qqs OCA], [http://www.ebi.ac.uk/pdbsum/2qqs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qqs RCSB]</span>
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}}
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'''JMJD2A tandem tudor domains in complex with a trimethylated histone H4-K20 peptide'''
'''JMJD2A tandem tudor domains in complex with a trimethylated histone H4-K20 peptide'''
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[[Category: Lee, J.]]
[[Category: Lee, J.]]
[[Category: Mer, G.]]
[[Category: Mer, G.]]
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[[Category: chromatin regulator]]
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[[Category: Chromatin regulator]]
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[[Category: dioxygenase]]
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[[Category: Dioxygenase]]
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[[Category: histone lysine demethylase]]
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[[Category: Histone lysine demethylase]]
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[[Category: host-virus interaction]]
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[[Category: Host-virus interaction]]
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[[Category: iron]]
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[[Category: Iron]]
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[[Category: metal binding protein]]
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[[Category: Metal binding protein]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: protein-methylated peptide complex]]
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[[Category: Protein-methylated peptide complex]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: zinc]]
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[[Category: Zinc]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:26:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:52:21 2008''
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Revision as of 12:26, 4 May 2008

Image:2qqs.jpg

Template:STRUCTURE 2qqs

JMJD2A tandem tudor domains in complex with a trimethylated histone H4-K20 peptide


Overview

The lysine demethylase JMJD2A has the unique property of binding trimethylated peptides from two different histone sequences (H3K4me3 and H4K20me3) through its tudor domains. Here we show using X-ray crystallography and calorimetry that H3K4me3 and H4K20me3, which are recognized with similar affinities by JMJD2A, adopt radically different binding modes, to the extent that we were able to design single point mutations in JMJD2A that inhibited the recognition of H3K4me3 but not H4K20me3 and vice versa.

About this Structure

2QQS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor., Lee J, Thompson JR, Botuyan MV, Mer G, Nat Struct Mol Biol. 2008 Jan;15(1):109-11. Epub 2007 Dec 16. PMID:18084306 Page seeded by OCA on Sun May 4 15:26:40 2008

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