2qr7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2qr7.jpg|left|200px]]
[[Image:2qr7.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2qr7 |SIZE=350|CAPTION= <scene name='initialview01'>2qr7</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_2qr7", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Rps6ka3, Rps6ka-rs1, Rsk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2qr7| PDB=2qr7 | SCENE= }}
-
|RELATEDENTRY=[[2qr8|2QR8]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qr7 OCA], [http://www.ebi.ac.uk/pdbsum/2qr7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qr7 RCSB]</span>
+
-
}}
+
'''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative'''
'''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative'''
Line 29: Line 26:
[[Category: Malakhova, M.]]
[[Category: Malakhova, M.]]
[[Category: Tereshko, V.]]
[[Category: Tereshko, V.]]
-
[[Category: atp-binding]]
+
[[Category: Atp-binding]]
-
[[Category: autoinhibitory]]
+
[[Category: Autoinhibitory]]
-
[[Category: kinase domain]]
+
[[Category: Kinase domain]]
-
[[Category: nucleotide-binding]]
+
[[Category: Nucleotide-binding]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: rsk2]]
+
[[Category: Rsk2]]
-
[[Category: serine/threonine-protein kinase]]
+
[[Category: Serine/threonine-protein kinase]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:28:21 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:52:22 2008''
+

Revision as of 12:28, 4 May 2008

Image:2qr7.jpg

Template:STRUCTURE 2qr7

2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative


Overview

The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

About this Structure

2QR7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2., Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z, Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:18084304 Page seeded by OCA on Sun May 4 15:28:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qr7"
Personal tools