2qsf

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[[Image:2qsf.jpg|left|200px]]
[[Image:2qsf.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qsf |SIZE=350|CAPTION= <scene name='initialview01'>2qsf</scene>, resolution 2.350&Aring;
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The line below this paragraph, containing "STRUCTURE_2qsf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= RAD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), RAD23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_2qsf| PDB=2qsf | SCENE= }}
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|RELATEDENTRY=[[2qsg|2QSG]], [[2qsh|2QSH]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qsf OCA], [http://www.ebi.ac.uk/pdbsum/2qsf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qsf RCSB]</span>
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}}
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'''Crystal structure of the Rad4-Rad23 complex'''
'''Crystal structure of the Rad4-Rad23 complex'''
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[[Category: Min, J H.]]
[[Category: Min, J H.]]
[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
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[[Category: alpha-beta structure]]
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[[Category: Alpha-beta structure]]
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[[Category: beta hairpin]]
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[[Category: Beta hairpin]]
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[[Category: dna binding protein]]
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[[Category: Dna binding protein]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: dna-damage recognition]]
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[[Category: Dna-damage recognition]]
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[[Category: nucleotide excision repair]]
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[[Category: Nucleotide excision repair]]
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[[Category: transglutaminase fold]]
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[[Category: Transglutaminase fold]]
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[[Category: xeroderma pigmentosum]]
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[[Category: Xeroderma pigmentosum]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:35:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:52:47 2008''
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Revision as of 12:35, 4 May 2008

Image:2qsf.jpg

Template:STRUCTURE 2qsf

Crystal structure of the Rad4-Rad23 complex


Overview

Mutations in the nucleotide excision repair (NER) pathway can cause the xeroderma pigmentosum skin cancer predisposition syndrome. NER lesions are limited to one DNA strand, but otherwise they are chemically and structurally diverse, being caused by a wide variety of genotoxic chemicals and ultraviolet radiation. The xeroderma pigmentosum C (XPC) protein has a central role in initiating global-genome NER by recognizing the lesion and recruiting downstream factors. Here we present the crystal structure of the yeast XPC orthologue Rad4 bound to DNA containing a cyclobutane pyrimidine dimer (CPD) lesion. The structure shows that Rad4 inserts a beta-hairpin through the DNA duplex, causing the two damaged base pairs to flip out of the double helix. The expelled nucleotides of the undamaged strand are recognized by Rad4, whereas the two CPD-linked nucleotides become disordered. These findings indicate that the lesions recognized by Rad4/XPC thermodynamically destabilize the Watson-Crick double helix in a manner that facilitates the flipping-out of two base pairs.

About this Structure

2QSF is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Recognition of DNA damage by the Rad4 nucleotide excision repair protein., Min JH, Pavletich NP, Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19. PMID:17882165 Page seeded by OCA on Sun May 4 15:35:06 2008

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