2qvs

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[[Image:2qvs.jpg|left|200px]]
[[Image:2qvs.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qvs |SIZE=350|CAPTION= <scene name='initialview01'>2qvs</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2qvs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Prkaca, Pkaca ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Prkar2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_2qvs| PDB=2qvs | SCENE= }}
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|RELATEDENTRY=[[1u7e|1u7e]], [[1cx4|1cx4]], [[1rgs|1rgs]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qvs OCA], [http://www.ebi.ac.uk/pdbsum/2qvs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qvs RCSB]</span>
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}}
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'''Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase'''
'''Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase'''
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: cAMP-dependent protein kinase]]
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[[Category: CAMP-dependent protein kinase]]
[[Category: Brown, S H.J.]]
[[Category: Brown, S H.J.]]
[[Category: Daake, S von.]]
[[Category: Daake, S von.]]
[[Category: Taylor, S S.]]
[[Category: Taylor, S S.]]
[[Category: Wu, J.]]
[[Category: Wu, J.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: camp-binding]]
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[[Category: Camp-binding]]
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[[Category: camp-dependent protein kinase]]
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[[Category: Camp-dependent protein kinase]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: isoform diversity]]
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[[Category: Isoform diversity]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: myristate]]
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[[Category: Myristate]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: transferase/transferase regulator complex]]
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[[Category: Transferase/transferase regulator complex]]
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[[Category: type iia holoenzyme]]
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[[Category: Type iia holoenzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:46:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:53:50 2008''
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Revision as of 12:46, 4 May 2008

Image:2qvs.jpg

Template:STRUCTURE 2qvs

Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase


Overview

The catalytic (C) subunit of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is inhibited by two classes of regulatory subunits, RI and RII. The RII subunits are substrates as well as inhibitors and do not require adenosine triphosphate (ATP) to form holoenzyme, which distinguishes them from RI subunits. To understand the molecular basis for isoform diversity, we solved the crystal structure of an RIIalpha holoenzyme and compared it to the RIalpha holoenzyme. Unphosphorylated RIIalpha(90-400), a deletion mutant, undergoes major conformational changes as both of the cAMP-binding domains wrap around the C subunit's large lobe. The hallmark of this conformational reorganization is the helix switch in domain A. The C subunit is in an open conformation, and its carboxyl-terminal tail is disordered. This structure demonstrates the conserved and isoform-specific features of RI and RII and the importance of ATP, and also provides a new paradigm for designing isoform-specific activators or antagonists for PKA.

About this Structure

2QVS is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity., Wu J, Brown SH, von Daake S, Taylor SS, Science. 2007 Oct 12;318(5848):274-9. PMID:17932298 Page seeded by OCA on Sun May 4 15:46:29 2008

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