2qxl

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[[Image:2qxl.jpg|left|200px]]
[[Image:2qxl.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qxl |SIZE=350|CAPTION= <scene name='initialview01'>2qxl</scene>, resolution 2.410&Aring;
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The line below this paragraph, containing "STRUCTURE_2qxl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= SSE1, MSI3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_2qxl| PDB=2qxl | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxl OCA], [http://www.ebi.ac.uk/pdbsum/2qxl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qxl RCSB]</span>
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}}
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'''Crystal Structure Analysis of Sse1, a yeast Hsp110'''
'''Crystal Structure Analysis of Sse1, a yeast Hsp110'''
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[[Category: Hendrickson, W A.]]
[[Category: Hendrickson, W A.]]
[[Category: Liu, Q.]]
[[Category: Liu, Q.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: atp state]]
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[[Category: Atp state]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: calmodulin-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: hsp110]]
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[[Category: Hsp110]]
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[[Category: hsp70]]
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[[Category: Hsp70]]
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[[Category: molecular chaperone]]
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[[Category: Molecular chaperone]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: stress response]]
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[[Category: Stress response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:52:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:54:28 2008''
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Revision as of 12:52, 4 May 2008

Image:2qxl.jpg

Template:STRUCTURE 2qxl

Crystal Structure Analysis of Sse1, a yeast Hsp110


Overview

Classic Hsp70 chaperones assist in diverse processes of protein folding and translocation, and Hsp110s had seemed by sequence to be distant relatives within an Hsp70 superfamily. The 2.4 A resolution structure of Sse1 with ATP shows that Hsp110s are indeed Hsp70 relatives, and it provides insight into allosteric coupling between sites for ATP and polypeptide-substrate binding in Hsp70s. Subdomain structures are similar in intact Sse1(ATP) and in the separate Hsp70 domains, but conformational dispositions are radically different. Interfaces between Sse1 domains are extensive, intimate, and conservative in sequence with Hsp70s. We propose that Sse1(ATP) may be an evolutionary vestige of the Hsp70(ATP) state, and an analysis of 64 mutant variants in Sse1 and three Hsp70 homologs supports this hypothesis. An atomic-level understanding of Hsp70 communication between ATP and substrate-binding domains follows. Requirements on Sse1 for yeast viability are in keeping with the distinct function of Hsp110s as nucleotide exchange factors.

About this Structure

2QXL is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Insights into hsp70 chaperone activity from a crystal structure of the yeast Hsp110 Sse1., Liu Q, Hendrickson WA, Cell. 2007 Oct 5;131(1):106-20. PMID:17923091 Page seeded by OCA on Sun May 4 15:52:18 2008

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OCA

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