2qxw

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[[Image:2qxw.jpg|left|200px]]
[[Image:2qxw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qxw |SIZE=350|CAPTION= <scene name='initialview01'>2qxw</scene>, resolution 0.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2qxw", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Residue+A+318'>AC1</scene>, <scene name='pdbsite=AC2:Ldt+Binding+Site+For+Residue+A+320'>AC2</scene>, <scene name='pdbsite=AC3:Cit+Binding+Site+For+Residue+A+400'>AC3</scene> and <scene name='pdbsite=AC4:Cit+Binding+Site+For+Residue+A+450'>AC4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2qxw| PDB=2qxw | SCENE= }}
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|RELATEDENTRY=[[1us0|1US0]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxw OCA], [http://www.ebi.ac.uk/pdbsum/2qxw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qxw RCSB]</span>
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}}
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'''Perdeuterated alr2 in complex with idd594'''
'''Perdeuterated alr2 in complex with idd594'''
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[[Category: Ruiz, F.]]
[[Category: Ruiz, F.]]
[[Category: Ventura, O.]]
[[Category: Ventura, O.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: cataract]]
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[[Category: Cataract]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: idd594]]
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[[Category: Idd594]]
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[[Category: nadp]]
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[[Category: Nadp]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:52:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:54:37 2008''
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Revision as of 12:53, 4 May 2008

Image:2qxw.jpg

Template:STRUCTURE 2qxw

Perdeuterated alr2 in complex with idd594


Overview

We present results of combined studies of the enzyme human aldose reductase (h-AR, 36 kDa) using single-crystal x-ray data (0.66 A, 100K; 0.80 A, 15K; 1.75 A, 293K), neutron Laue data (2.2 A, 293K), and quantum mechanical modeling. These complementary techniques unveil the internal organization and mobility of the hydrogen bond network that defines the properties of the catalytic engine, explaining how this promiscuous enzyme overcomes the simultaneous requirements of efficiency and promiscuity offering a general mechanistic view for this class of enzymes.

About this Structure

2QXW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase., Blakeley MP, Ruiz F, Cachau R, Hazemann I, Meilleur F, Mitschler A, Ginell S, Afonine P, Ventura ON, Cousido-Siah A, Haertlein M, Joachimiak A, Myles D, Podjarny A, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1844-8. Epub 2008 Feb 4. PMID:18250329 Page seeded by OCA on Sun May 4 15:52:57 2008

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OCA

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