2qyf

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[[Image:2qyf.jpg|left|200px]]
[[Image:2qyf.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qyf |SIZE=350|CAPTION= <scene name='initialview01'>2qyf</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2qyf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= MAD2L1, MAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), MAD2L1BP, CMT2, KIAA0110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2qyf| PDB=2qyf | SCENE= }}
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|RELATEDENTRY=[[1s2h|1S2H]], [[1klq|1KLQ]], [[1duj|1DUJ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qyf OCA], [http://www.ebi.ac.uk/pdbsum/2qyf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qyf RCSB]</span>
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}}
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'''Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex'''
'''Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex'''
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[[Category: Luo, X.]]
[[Category: Luo, X.]]
[[Category: Tomchick, D R.]]
[[Category: Tomchick, D R.]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: mad2 family]]
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[[Category: Mad2 family]]
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[[Category: mitosis]]
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[[Category: Mitosis]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protein-peptide complex]]
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[[Category: Protein-peptide complex]]
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[[Category: spindle assembly checkpoint]]
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[[Category: Spindle assembly checkpoint]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:54:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:54:43 2008''
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Revision as of 12:54, 4 May 2008

Image:2qyf.jpg

Template:STRUCTURE 2qyf

Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex


Overview

The status of spindle checkpoint signaling depends on the balance of two opposing dynamic processes that regulate the highly unusual two-state behavior of Mad2. In mitosis, a Mad1-Mad2 core complex recruits cytosolic Mad2 to kinetochores through Mad2 dimerization and converts Mad2 to a conformer amenable to Cdc20 binding, thereby facilitating checkpoint activation. p31(comet) inactivates the checkpoint through binding to Mad1- or Cdc20-bound Mad2, thereby preventing Mad2 activation and promoting the dissociation of the Mad2-Cdc20 complex. Here, we report the crystal structure of the Mad2-p31(comet) complex. The C-terminal region of Mad2 that undergoes rearrangement in different Mad2 conformers is a major structural determinant for p31(comet) binding, explaining the specificity of p31(comet) toward Mad1- or Cdc20-bound Mad2. p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2."

About this Structure

2QYF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

p31comet blocks Mad2 activation through structural mimicry., Yang M, Li B, Tomchick DR, Machius M, Rizo J, Yu H, Luo X, Cell. 2007 Nov 16;131(4):744-55. PMID:18022368 Page seeded by OCA on Sun May 4 15:54:48 2008

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OCA

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