2qyu

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[[Image:2qyu.jpg|left|200px]]
[[Image:2qyu.jpg|left|200px]]
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{{Structure
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|PDB= 2qyu |SIZE=350|CAPTION= <scene name='initialview01'>2qyu</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2qyu", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= sopA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
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|DOMAIN=
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{{STRUCTURE_2qyu| PDB=2qyu | SCENE= }}
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|RELATEDENTRY=[[2qza|2QZA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qyu OCA], [http://www.ebi.ac.uk/pdbsum/2qyu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qyu RCSB]</span>
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'''Crystal structure of Salmonella effector protein SopA'''
'''Crystal structure of Salmonella effector protein SopA'''
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[[Category: Chen, J.]]
[[Category: Chen, J.]]
[[Category: Diao, J.]]
[[Category: Diao, J.]]
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[[Category: ubiquitin e3 ligase]]
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[[Category: Ubiquitin e3 ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:55:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:54:46 2008''
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Revision as of 12:55, 4 May 2008

Image:2qyu.jpg

Template:STRUCTURE 2qyu

Crystal structure of Salmonella effector protein SopA


Overview

Bacterial pathogens deliver virulence proteins into host cells to facilitate entry and survival. Salmonella SopA functions as an E3 ligase to manipulate the host proinflammatory response. Here we report the crystal structure of SopA in two conformations. Although it has little sequence similarity to eukaryotic HECT-domain E3s, the C-terminal half of SopA has a bilobal architecture that is reminiscent of the N- and C-lobe arrangement of HECT domains. The SopA structure also contains a putative substrate-binding domain located near the E2-binding site. The two structures of SopA differ in the relative orientations of the C lobe, indicating that SopA possesses the conformational flexibility essential for HECT E3 function. These results suggest that SopA is a unique HECT E3 ligase evolved from the coevolutionary selective pressure at the bacterium-host interface.

About this Structure

2QYU is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase., Diao J, Zhang Y, Huibregtse JM, Zhou D, Chen J, Nat Struct Mol Biol. 2008 Jan;15(1):65-70. Epub 2007 Dec 9. PMID:18066077 Page seeded by OCA on Sun May 4 15:55:39 2008

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