2r2w

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[[Image:2r2w.jpg|left|200px]]
[[Image:2r2w.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2r2w |SIZE=350|CAPTION= <scene name='initialview01'>2r2w</scene>, resolution 2.01&Aring;
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The line below this paragraph, containing "STRUCTURE_2r2w", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=4PG:1-[4-(2-OXO-2-PHENYLETHYL)PHENYL]GUANIDINE'>4PG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2r2w| PDB=2r2w | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2w OCA], [http://www.ebi.ac.uk/pdbsum/2r2w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r2w RCSB]</span>
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}}
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'''Urokinase plasminogen activator B-chain-GPPE complex'''
'''Urokinase plasminogen activator B-chain-GPPE complex'''
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[[Category: U-plasminogen activator]]
[[Category: U-plasminogen activator]]
[[Category: Zeslawska, E.]]
[[Category: Zeslawska, E.]]
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[[Category: egf-like domain]]
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[[Category: Egf-like domain]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: kringle]]
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[[Category: Kringle]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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[[Category: urokinase]]
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[[Category: Urokinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:08:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:00 2008''
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Revision as of 13:08, 4 May 2008

Image:2r2w.jpg

Template:STRUCTURE 2r2w

Urokinase plasminogen activator B-chain-GPPE complex


Contents

Overview

Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two different environments was determined in order to compare the binding geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a target for anti-cancer drugs. It was shown that the conformation and the hydrogen-bonding formation by GPPE molecule are similar in both environments, but several important differences were discovered and described.

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

2R2W is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator., Zeslawska E, Sturzebecher J, Oleksyn BJ, Bioorg Med Chem Lett. 2007 Nov 15;17(22):6212-5. Epub 2007 Sep 8. PMID:17905583 Page seeded by OCA on Sun May 4 16:08:28 2008

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OCA

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