2r5q

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[[Image:2r5q.jpg|left|200px]]
[[Image:2r5q.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2r5q |SIZE=350|CAPTION= <scene name='initialview01'>2r5q</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2r5q", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=1UN:2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL+SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC+ACID+TERT-BUTYLAMIDE'>1UN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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|GENE= pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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|DOMAIN=
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{{STRUCTURE_2r5q| PDB=2r5q | SCENE= }}
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|RELATEDENTRY=[[2r5p|2R5P]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5q OCA], [http://www.ebi.ac.uk/pdbsum/2r5q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r5q RCSB]</span>
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'''Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Nelfinavir'''
'''Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Nelfinavir'''
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[[Category: McKenna, R.]]
[[Category: McKenna, R.]]
[[Category: Robbins, A H.]]
[[Category: Robbins, A H.]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: hiv-1 subtype c]]
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[[Category: Hiv-1 subtype c]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: viral protein]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:17:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:50 2008''
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Revision as of 13:17, 4 May 2008

Image:2r5q.jpg

Template:STRUCTURE 2r5q

Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Nelfinavir


Overview

Fourteen subtype B and C protease variants have been engineered in an effort to study whether the preexistent baseline polymorphisms, by themselves or in combination with drug resistance mutations, differentially alter the biochemical and structural features of the subtype C protease when compared with those of subtype B protease. The kinetic studies performed in this work showed that the preexistent polymorphisms in subtype C protease, by themselves, do not provide for a greater level of resistance. Inhibition analysis with eight clinically used protease inhibitors revealed that the natural polymorphisms found in subtype C protease, in combination with drug resistance mutations, can influence enzymatic catalytic efficiency and inhibitor resistance. Structural analyses of the subtype C protease bound to nelfinavir and indinavir showed that these inhibitors form similar interactions with the residues in the active site of subtype B and C proteases. It also revealed that the naturally occurring polymorphisms could alter the position of the outer loops of the subtype C protease, especially the 60's loop.

About this Structure

2R5Q is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease., Coman RM, Robbins AH, Fernandez MA, Gilliland CT, Sochet AA, Goodenow MM, McKenna R, Dunn BM, Biochemistry. 2008 Jan 15;47(2):731-43. Epub 2007 Dec 20. PMID:18092815 Page seeded by OCA on Sun May 4 16:17:48 2008

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