2r6a

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[[Image:2r6a.jpg|left|200px]]
[[Image:2r6a.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2r6a |SIZE=350|CAPTION= <scene name='initialview01'>2r6a</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2r6a", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= DnaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus]), DnaG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])
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-->
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|DOMAIN=
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{{STRUCTURE_2r6a| PDB=2r6a | SCENE= }}
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|RELATEDENTRY=[[2r6c|2R6C]], [[2r6d|2R6D]], [[2r6e|2R6E]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6a OCA], [http://www.ebi.ac.uk/pdbsum/2r6a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r6a RCSB]</span>
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}}
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'''Crystal Form BH1'''
'''Crystal Form BH1'''
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[[Category: Eliason, W K.]]
[[Category: Eliason, W K.]]
[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
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[[Category: dnab]]
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[[Category: Dnab]]
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[[Category: dnag]]
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[[Category: Dnag]]
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[[Category: helicase]]
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[[Category: Helicase]]
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[[Category: primase]]
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[[Category: Primase]]
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[[Category: replication]]
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[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:19:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:58 2008''
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Revision as of 13:19, 4 May 2008

Image:2r6a.jpg

Template:STRUCTURE 2r6a

Crystal Form BH1


Overview

The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.

About this Structure

2R6A is a Protein complex structure of sequences from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:17947583 Page seeded by OCA on Sun May 4 16:19:20 2008

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