2r6e

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[[Image:2r6e.jpg|left|200px]]
[[Image:2r6e.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2r6e |SIZE=350|CAPTION= <scene name='initialview01'>2r6e</scene>, resolution 5.019&Aring;
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The line below this paragraph, containing "STRUCTURE_2r6e", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= DnaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])
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|DOMAIN=
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{{STRUCTURE_2r6e| PDB=2r6e | SCENE= }}
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|RELATEDENTRY=[[2r6a|2R6A]], [[2r6c|2R6C]], [[2r6d|2R6D]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6e OCA], [http://www.ebi.ac.uk/pdbsum/2r6e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r6e RCSB]</span>
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}}
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'''Crystal Form B2'''
'''Crystal Form B2'''
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[[Category: Eliason, W K.]]
[[Category: Eliason, W K.]]
[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
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[[Category: helicase]]
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[[Category: Helicase]]
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[[Category: hexameric]]
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[[Category: Hexameric]]
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[[Category: replication dnab]]
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[[Category: Replication dnab]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:19:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:57 2008''
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Revision as of 13:19, 4 May 2008

Image:2r6e.jpg

Template:STRUCTURE 2r6e

Crystal Form B2


Overview

The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.

About this Structure

2R6E is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:17947583 Page seeded by OCA on Sun May 4 16:19:24 2008

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