2r7g

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[[Image:2r7g.gif|left|200px]]
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{{Structure
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|GENE= RB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r7g OCA], [http://www.ebi.ac.uk/pdbsum/2r7g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r7g RCSB]</span>
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'''Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain'''
'''Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain'''
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[[Category: Liu, X.]]
[[Category: Liu, X.]]
[[Category: Marmorstein, R.]]
[[Category: Marmorstein, R.]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: e1a]]
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[[Category: E1a]]
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[[Category: e2f displacement]]
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[[Category: E2f displacement]]
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[[Category: retinoblastoma protein]]
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[[Category: Retinoblastoma protein]]
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[[Category: transcription repressor]]
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[[Category: Transcription repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:23:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:57:20 2008''
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Revision as of 13:23, 4 May 2008

Image:2r7g.gif

Template:STRUCTURE 2r7g

Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain


Contents

Overview

The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.

Disease

Known disease associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]

About this Structure

2R7G is a Protein complex structure of sequences from Homo sapiens and Human adenovirus 5. Full crystallographic information is available from OCA.

Reference

Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914 Page seeded by OCA on Sun May 4 16:23:11 2008

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