2r9r

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[[Image:2r9r.jpg|left|200px]]
[[Image:2r9r.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2r9r |SIZE=350|CAPTION= <scene name='initialview01'>2r9r</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_2r9r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Kcnab2, Ckbeta2, Kcnb3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), kcna2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_2r9r| PDB=2r9r | SCENE= }}
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|RELATEDENTRY=[[2a79|2a79]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9r OCA], [http://www.ebi.ac.uk/pdbsum/2r9r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r9r RCSB]</span>
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}}
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'''Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit'''
'''Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit'''
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[[Category: Mackinnon, R.]]
[[Category: Mackinnon, R.]]
[[Category: Tao, X.]]
[[Category: Tao, X.]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: eukaryotic]]
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[[Category: Eukaryotic]]
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[[Category: ion channel]]
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[[Category: Ion channel]]
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[[Category: ion transport]]
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[[Category: Ion transport]]
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[[Category: ionic channel]]
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[[Category: Ionic channel]]
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[[Category: kv1 2]]
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[[Category: Kv1 2]]
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[[Category: kv2 1]]
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[[Category: Kv2 1]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: nadp]]
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[[Category: Nadp]]
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[[Category: paddle chimera channel]]
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[[Category: Paddle chimera channel]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: potassium channel]]
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[[Category: Potassium channel]]
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[[Category: potassium transport]]
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[[Category: Potassium transport]]
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[[Category: protein transport]]
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[[Category: Protein transport]]
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[[Category: shaker]]
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[[Category: Shaker]]
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[[Category: transport]]
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[[Category: Transport]]
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[[Category: transport protein]]
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[[Category: Transport protein]]
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[[Category: voltage dependent]]
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[[Category: Voltage dependent]]
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[[Category: voltage sensor]]
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[[Category: Voltage sensor]]
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[[Category: voltage-gated channel]]
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[[Category: Voltage-gated channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:29:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:06 2008''
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Revision as of 13:29, 4 May 2008

Image:2r9r.jpg

Template:STRUCTURE 2r9r

Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit


Overview

Voltage-dependent K+ (Kv) channels repolarize the action potential in neurons and muscle. This type of channel is gated directly by membrane voltage through protein domains known as voltage sensors, which are molecular voltmeters that read the membrane voltage and regulate the pore. Here we describe the structure of a chimaeric voltage-dependent K+ channel, which we call the 'paddle-chimaera channel', in which the voltage-sensor paddle has been transferred from Kv2.1 to Kv1.2. Crystallized in complex with lipids, the complete structure at 2.4 angstrom resolution reveals the pore and voltage sensors embedded in a membrane-like arrangement of lipid molecules. The detailed structure, which can be compared directly to a large body of functional data, explains charge stabilization within the membrane and suggests a mechanism for voltage-sensor movements and pore gating.

About this Structure

2R9R is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment., Long SB, Tao X, Campbell EB, MacKinnon R, Nature. 2007 Nov 15;450(7168):376-82. PMID:18004376 Page seeded by OCA on Sun May 4 16:29:47 2008

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