2ra4

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[[Image:2ra4.jpg|left|200px]]
[[Image:2ra4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ra4 |SIZE=350|CAPTION= <scene name='initialview01'>2ra4</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2ra4", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+76'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+77'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+B+76'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+77'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+A+78'>AC5</scene>, <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+B+78'>AC6</scene> and <scene name='pdbsite=AC7:Tfa+Binding+Site+For+Residue+B+79'>AC7</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETYL+GROUP'>TFA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= CCL13, MCP4, NCC1, SCYA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2ra4| PDB=2ra4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ra4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ra4 OCA], [http://www.ebi.ac.uk/pdbsum/2ra4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ra4 RCSB]</span>
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}}
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'''Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)'''
'''Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)'''
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[[Category: Barinka, C.]]
[[Category: Barinka, C.]]
[[Category: Lubkowski, J.]]
[[Category: Lubkowski, J.]]
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[[Category: cc chemokine family]]
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[[Category: Cc chemokine family]]
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[[Category: ccl13]]
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[[Category: Ccl13]]
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[[Category: chemotaxis]]
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[[Category: Chemotaxis]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: inflammatory response]]
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[[Category: Inflammatory response]]
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[[Category: mcp-4]]
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[[Category: Mcp-4]]
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[[Category: monocyte]]
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[[Category: Monocyte]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: pyrrolidone carboxylic acid]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: secreted]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:31:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:04 2008''
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Revision as of 13:31, 4 May 2008

Image:2ra4.jpg

Template:STRUCTURE 2ra4

Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)


Overview

Monocyte chemoattractant proteins (MCPs) belong to the CC chemokine family and are involved in many (patho)physiological processes characterized by mononuclear cell infiltration, including tissue remodeling, atherosclerosis and cancer metastasis. Here, the crystal structure of human monocyte chemoattractant protein 4 (MCP-4) refined at 1.70 A resolution is reported with crystallographic values R = 0.180 and R(free) = 0.212. The overall MCP-4 fold reveals the typical tertiary features of the CC chemokine family. A central three-stranded antiparallel beta-sheet is C-terminally flanked by an overlaying alpha-helix, while the N-terminal part of the molecule forms an extended loop that is anchored to the rest of the molecule via two disulfide bridges, Cys11-Cys35 and Cys12-Cys51. The crystal packing suggests the existence of MCP-4 dimers with a dimerization interface similar to those previously reported for the X-ray structures of MCP-1 and MCP-2.

About this Structure

2RA4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13)., Barinka C, Prahl A, Lubkowski J, Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):273-8. Epub 2008, Feb 20. PMID:18323622 Page seeded by OCA on Sun May 4 16:31:06 2008

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