2ran

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[[Image:2ran.jpg|left|200px]]
[[Image:2ran.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2ran", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_2ran| PDB=2ran | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ran FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ran OCA], [http://www.ebi.ac.uk/pdbsum/2ran PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ran RCSB]</span>
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'''RAT ANNEXIN V CRYSTAL STRUCTURE: CA2+-INDUCED CONFORMATIONAL CHANGES'''
'''RAT ANNEXIN V CRYSTAL STRUCTURE: CA2+-INDUCED CONFORMATIONAL CHANGES'''
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[[Category: Kaetzel, M A.]]
[[Category: Kaetzel, M A.]]
[[Category: Seaton, B A.]]
[[Category: Seaton, B A.]]
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[[Category: calcium/phospholipid-binding protein]]
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[[Category: Calcium/phospholipid-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:33:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:20 2008''
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Revision as of 13:33, 4 May 2008

Image:2ran.jpg

Template:STRUCTURE 2ran

RAT ANNEXIN V CRYSTAL STRUCTURE: CA2+-INDUCED CONFORMATIONAL CHANGES


Overview

Annexins are a family of calcium- and phospholipid-binding proteins implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of rat annexin V was solved to 1.9 angstrom resolution by multiple isomorphous replacement. Unlike previously solved annexin V structures, all four domains bound calcium in this structure. Calcium binding in the third domain induced a large relocation of the calcium-binding loop regions, exposing the single tryptophan residue to the solvent. These alterations in annexin V suggest a role for domain 3 in calcium-triggered interaction with phospholipid membranes.

About this Structure

2RAN is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Rat annexin V crystal structure: Ca(2+)-induced conformational changes., Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA, Science. 1993 Sep 3;261(5126):1321-4. PMID:8362244 Page seeded by OCA on Sun May 4 16:33:31 2008

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OCA

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