2rat

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[[Image:2rat.jpg|left|200px]]
[[Image:2rat.jpg|left|200px]]
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{{Structure
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|PDB= 2rat |SIZE=350|CAPTION= <scene name='initialview01'>2rat</scene>, resolution 1.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2rat", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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{{STRUCTURE_2rat| PDB=2rat | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rat OCA], [http://www.ebi.ac.uk/pdbsum/2rat PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rat RCSB]</span>
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'''EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K'''
'''EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K'''
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[[Category: Petsko, G A.]]
[[Category: Petsko, G A.]]
[[Category: Tiltonjunior, R F.]]
[[Category: Tiltonjunior, R F.]]
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[[Category: hydrolase (nucleic acid,rna)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:33:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:22 2008''
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Revision as of 13:33, 4 May 2008

Image:2rat.jpg

Template:STRUCTURE 2rat

EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K


Overview

Structures using X-ray diffraction data collected to 1.5-A resolution have been determined for the protein ribonuclease-A at nine different temperatures ranging from 98 to 320 K. It is determined that the protein molecule expands slightly (0.4% per 100 K) with increasing temperature and that this expansion is linear. The expansion is due primarily to subtle repacking of the molecule, with exposed and mobile loop regions exhibiting the largest movements. Individual atomic Debye-Waller factors exhibit predominantly biphasic behavior, with a small positive slope at low temperatures and a larger positive slope at higher temperatures. The break in this curve occurs at a characteristic temperature of 180-200 K, perhaps indicative of fundamental changes in the dynamical structure of the surrounding protein solvent. The distribution of protein Debye-Waller factors is observed to broaden as well as shift to higher values as the temperature is increased.

About this Structure

2RAT is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Effects of temperature on protein structure and dynamics: X-ray crystallographic studies of the protein ribonuclease-A at nine different temperatures from 98 to 320 K., Tilton RF Jr, Dewan JC, Petsko GA, Biochemistry. 1992 Mar 10;31(9):2469-81. PMID:1547232 Page seeded by OCA on Sun May 4 16:33:55 2008

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