2rcv

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[[Image:2rcv.jpg|left|200px]]
[[Image:2rcv.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rcv |SIZE=350|CAPTION= <scene name='initialview01'>2rcv</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2rcv", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+G+203'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+203'>AC2</scene>, <scene name='pdbsite=AC3:Mn+Binding+Site+For+Residue+E+203'>AC3</scene>, <scene name='pdbsite=AC4:Mn+Binding+Site+For+Residue+F+203'>AC4</scene>, <scene name='pdbsite=AC5:Mn+Binding+Site+For+Residue+B+203'>AC5</scene>, <scene name='pdbsite=AC6:Mn+Binding+Site+For+Residue+C+203'>AC6</scene>, <scene name='pdbsite=AC7:Mn+Binding+Site+For+Residue+D+203'>AC7</scene> and <scene name='pdbsite=AC8:Mn+Binding+Site+For+Residue+H+203'>AC8</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= sodA, yqgD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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-->
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|DOMAIN=
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{{STRUCTURE_2rcv| PDB=2rcv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcv OCA], [http://www.ebi.ac.uk/pdbsum/2rcv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rcv RCSB]</span>
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}}
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'''Crystal structure of the Bacillus subtilis superoxide dismutase'''
'''Crystal structure of the Bacillus subtilis superoxide dismutase'''
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[[Category: Tai, P C]]
[[Category: Tai, P C]]
[[Category: Weber, I T]]
[[Category: Weber, I T]]
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[[Category: bacillus subtilis,superoxide dismutase]]
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[[Category: Bacillus subtilis,superoxide dismutase]]
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[[Category: manganese]]
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[[Category: Manganese]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: stress response]]
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[[Category: Stress response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:39:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:58 2008''
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Revision as of 13:39, 4 May 2008

Image:2rcv.jpg

Template:STRUCTURE 2rcv

Crystal structure of the Bacillus subtilis superoxide dismutase


Overview

The sodA gene of Bacillus subtilis was expressed in Escherichia coli, purified and crystallized. The crystal structure of MnSOD was solved by molecular replacement with four dimers per asymmetric unit and refined to an R factor of 21.1% at 1.8 A resolution. The dimer structure is very similar to that of the related enzyme from B. anthracis. Larger structural differences were observed with the human MnSOD, which has one less helix in the helical domain and a longer loop between two beta-strands and also showed differences in three amino acids at the intersubunit interface in the dimer compared with the two bacterial MnSODs. These structural differences can be exploited in the design of drugs that selectively target the Bacillus enzymes.

About this Structure

2RCV is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structure of Bacillus subtilis superoxide dismutase., Liu P, Ewis HE, Huang YJ, Lu CD, Tai PC, Weber IT, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt, 12):1003-7. Epub 2007 Nov 21. PMID:18084079 Page seeded by OCA on Sun May 4 16:39:30 2008

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