2rcz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2rcz.jpg|left|200px]]
[[Image:2rcz.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2rcz |SIZE=350|CAPTION= <scene name='initialview01'>2rcz</scene>, resolution 1.700&Aring;
+
The line below this paragraph, containing "STRUCTURE_2rcz", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= TJP1, ZO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2rcz| PDB=2rcz | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcz OCA], [http://www.ebi.ac.uk/pdbsum/2rcz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rcz RCSB]</span>
+
-
}}
+
'''Structure of the second PDZ domain of ZO-1'''
'''Structure of the second PDZ domain of ZO-1'''
Line 27: Line 24:
[[Category: Lavie, A.]]
[[Category: Lavie, A.]]
[[Category: Lye, M F.]]
[[Category: Lye, M F.]]
-
[[Category: cell junction]]
+
[[Category: Cell junction]]
-
[[Category: domain-swapping]]
+
[[Category: Domain-swapping]]
-
[[Category: membrane]]
+
[[Category: Membrane]]
-
[[Category: pdz]]
+
[[Category: Pdz]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: protein binding]]
+
[[Category: Protein binding]]
-
[[Category: sh3 domain]]
+
[[Category: Sh3 domain]]
-
[[Category: tight junction]]
+
[[Category: Tight junction]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:39:56 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:02 2008''
+

Revision as of 13:39, 4 May 2008

Image:2rcz.jpg

Template:STRUCTURE 2rcz

Structure of the second PDZ domain of ZO-1


Overview

ZO-1 is a multidomain protein involved in cell-cell junctions and contains three PDZ domains, which are necessary for its function in vivo. PDZ domains play a central role in assembling diverse protein complexes through their ability to recognize short peptide motifs on other proteins. We determined the structure of the second of the three PDZ domains of ZO-1, which is known to promote dimerization as well as bind to C-terminal sequences on connexins. The dimer is stabilized by extensive symmetrical domain swapping of beta-strands, which is unlike any other known mechanism of PDZ dimerization. The canonical peptide-binding groove remains intact in both subunits of the PDZ2 dimer and is created by elements contributed from both monomers. This unique structure reveals an additional example of how PDZ domains dimerize and has multiple implications for both peptide binding and oligomerization in vivo.

About this Structure

2RCZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Domain swapping within PDZ2 is responsible for dimerization of ZO proteins., Fanning AS, Lye MF, Anderson JM, Lavie A, J Biol Chem. 2007 Dec 28;282(52):37710-6. Epub 2007 Oct 9. PMID:17928286 Page seeded by OCA on Sun May 4 16:39:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rcz"
Personal tools