2rf2

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[[Image:2rf2.jpg|left|200px]]
[[Image:2rf2.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rf2 |SIZE=350|CAPTION= <scene name='initialview01'>2rf2</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_2rf2", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mrx+Binding+Site+For+Residue+A+561'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MRX:5-BROMO-3-(PYRROLIDIN-1-YLSULFONYL)-1H-INDOLE-2-CARBOXAMIDE'>MRX</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_2rf2| PDB=2rf2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf2 OCA], [http://www.ebi.ac.uk/pdbsum/2rf2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rf2 RCSB]</span>
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}}
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'''HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)'''
'''HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)'''
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[[Category: Prasad, S.]]
[[Category: Prasad, S.]]
[[Category: Yan, Y.]]
[[Category: Yan, Y.]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: ai]]
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[[Category: Ai]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: capsid maturation]]
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[[Category: Capsid maturation]]
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[[Category: core protein]]
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[[Category: Core protein]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: dna integration]]
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[[Category: Dna integration]]
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[[Category: dna recombination]]
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[[Category: Dna recombination]]
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[[Category: dna-directed dna polymerase]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: endonuclease]]
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[[Category: Endonuclease]]
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[[Category: hiv-1 revers transcriptase]]
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[[Category: Hiv-1 revers transcriptase]]
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[[Category: host-virus interaction]]
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[[Category: Host-virus interaction]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Lipoprotein]]
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[[Category: Magnesium]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: multifunctional enzyme]]
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[[Category: Multifunctional enzyme]]
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[[Category: myristate]]
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[[Category: Myristate]]
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[[Category: non-nucleoside inhibition]]
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[[Category: Non-nucleoside inhibition]]
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[[Category: nuclease]]
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[[Category: Nuclease]]
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[[Category: nucleotidyltransferase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: rna-binding]]
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[[Category: Rna-binding]]
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[[Category: rna-directed dna polymerase]]
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[[Category: Rna-directed dna polymerase]]
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[[Category: viral nucleoprotein]]
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[[Category: Viral nucleoprotein]]
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[[Category: virion]]
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[[Category: Virion]]
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[[Category: zinc]]
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[[Category: Zinc]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:46:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:38 2008''
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Revision as of 13:46, 4 May 2008

Image:2rf2.jpg

Template:STRUCTURE 2rf2

HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)


Overview

This Letter describes the design, synthesis, and biological evaluation of novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.

About this Structure

2RF2 is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)., Zhao Z, Wolkenberg SE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley CW, Hartman GD, Vacca JP, Williams TM, Bioorg Med Chem Lett. 2008 Jan 15;18(2):554-9. Epub 2007 Nov 28. PMID:18083561 Page seeded by OCA on Sun May 4 16:46:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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