2rf3

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[[Image:2rf3.jpg|left|200px]]
[[Image:2rf3.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rf3 |SIZE=350|CAPTION= <scene name='initialview01'>2rf3</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_2rf3", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+B+308'>AC1</scene> and <scene name='pdbsite=AC2:Spm+Binding+Site+For+Residue+B+309'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>, <scene name='pdbligand=TCY:(2R,3AS,4AR,5AR,5BS)-2-(6-AMINO-9H-PURIN-9-YL)-3A-HYDROXYHEXAHYDROCYCLOPROPA[4,5]CYCLOPENTA[1,2-B]FURAN-5A(4H)-YL+DIHYDROGEN+PHOSPHATE'>TCY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2rf3| PDB=2rf3 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf3 OCA], [http://www.ebi.ac.uk/pdbsum/2rf3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rf3 RCSB]</span>
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}}
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'''Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles'''
'''Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles'''
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==About this Structure==
==About this Structure==
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2RF3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF3 OCA].
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2RF3 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF3 OCA].
==Reference==
==Reference==
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[[Category: Pallan, P S.]]
[[Category: Pallan, P S.]]
[[Category: Wawrzak, Z.]]
[[Category: Wawrzak, Z.]]
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[[Category: conformationally constrained dna analog]]
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[[Category: Conformationally constrained dna analog]]
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[[Category: dna duplex]]
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[[Category: Dna duplex]]
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[[Category: tricyclo-dna]]
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[[Category: Tricyclo-dna]]
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[[Category: x-ray crystal structure]]
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[[Category: X-ray crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:46:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:39 2008''
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Revision as of 13:46, 4 May 2008

Image:2rf3.jpg

Template:STRUCTURE 2rf3

Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles


Overview

The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.

About this Structure

2RF3 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles., Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M, Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:18253536 Page seeded by OCA on Sun May 4 16:46:56 2008

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OCA

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