2rf4

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[[Image:2rf4.jpg|left|200px]]
[[Image:2rf4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rf4 |SIZE=350|CAPTION= <scene name='initialview01'>2rf4</scene>, resolution 3.1&Aring;
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The line below this paragraph, containing "STRUCTURE_2rf4", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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|GENE= RPA43, RRN12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), RPA14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_2rf4| PDB=2rf4 | SCENE= }}
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|RELATEDENTRY=[[1y14|1Y14]], [[2ckz|2CKZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf4 OCA], [http://www.ebi.ac.uk/pdbsum/2rf4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rf4 RCSB]</span>
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}}
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'''Crystal structure of the RNA Polymerase I subcomplex A14/43'''
'''Crystal structure of the RNA Polymerase I subcomplex A14/43'''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:47:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:41 2008''
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Revision as of 13:47, 4 May 2008

Image:2rf4.jpg

Template:STRUCTURE 2rf4

Crystal structure of the RNA Polymerase I subcomplex A14/43


Overview

Synthesis of ribosomal RNA (rRNA) by RNA polymerase (Pol) I is the first step in ribosome biogenesis and a regulatory switch in eukaryotic cell growth. Here we report the 12 A cryo-electron microscopic structure for the complete 14-subunit yeast Pol I, a homology model for the core enzyme, and the crystal structure of the subcomplex A14/43. In the resulting hybrid structure of Pol I, A14/43, the clamp, and the dock domain contribute to a unique surface interacting with promoter-specific initiation factors. The Pol I-specific subunits A49 and A34.5 form a heterodimer near the enzyme funnel that acts as a built-in elongation factor and is related to the Pol II-associated factor TFIIF. In contrast to Pol II, Pol I has a strong intrinsic 3'-RNA cleavage activity, which requires the C-terminal domain of subunit A12.2 and, apparently, enables ribosomal RNA proofreading and 3'-end trimming.

About this Structure

2RF4 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Functional architecture of RNA polymerase I., Kuhn CD, Geiger SR, Baumli S, Gartmann M, Gerber J, Jennebach S, Mielke T, Tschochner H, Beckmann R, Cramer P, Cell. 2007 Dec 28;131(7):1260-72. PMID:18160037 Page seeded by OCA on Sun May 4 16:47:04 2008

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