2rft

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[[Image:2rft.jpg|left|200px]]
[[Image:2rft.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rft |SIZE=350|CAPTION= <scene name='initialview01'>2rft</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2rft", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+343'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+345'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Residue+A+346'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+A+347'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+348'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+349'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Residue+A+350'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Residue+A+351'>AC8</scene>, <scene name='pdbsite=AC9:Nag+Binding+Site+For+Residue+B+170'>AC9</scene>, <scene name='pdbsite=BC1:Sia+Binding+Site+For+Residue+A+3021'>BC1</scene>, <scene name='pdbsite=BC2:Bgc+Binding+Site+For+Residue+A+3025'>BC2</scene>, <scene name='pdbsite=BC3:Gal+Binding+Site+For+Residue+A+3024'>BC3</scene>, <scene name='pdbsite=BC4:Ndg+Binding+Site+For+Residue+A+3023'>BC4</scene> and <scene name='pdbsite=BC5:Gal+Binding+Site+For+Residue+A+3022'>BC5</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Hemagglutinin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11520 Influenza B virus])
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-->
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|DOMAIN=
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{{STRUCTURE_2rft| PDB=2rft | SCENE= }}
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|RELATEDENTRY=[[2rfu|2RFU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rft OCA], [http://www.ebi.ac.uk/pdbsum/2rft PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rft RCSB]</span>
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}}
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'''Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog'''
'''Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog'''
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[[Category: Tian, X.]]
[[Category: Tian, X.]]
[[Category: Wang, Q.]]
[[Category: Wang, Q.]]
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[[Category: envelope protein]]
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[[Category: Envelope protein]]
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[[Category: fusion protein]]
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[[Category: Fusion protein]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hemagglutinin]]
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[[Category: Hemagglutinin]]
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[[Category: influenza]]
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[[Category: Influenza]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: palmitate]]
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[[Category: Palmitate]]
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[[Category: receptor specificity]]
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[[Category: Receptor specificity]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: viral protein]]
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[[Category: Viral protein]]
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[[Category: virion]]
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[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:50:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:59 2008''
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Revision as of 13:50, 4 May 2008

Image:2rft.jpg

Template:STRUCTURE 2rft

Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog


Overview

Receptor-binding specificity of HA, the major surface glycoprotein of influenza virus, primarily determines the host ranges that the virus can infect. Influenza type B virus almost exclusively infects humans and contributes to the annual "flu" sickness. Here we report the structures of influenza B virus HA in complex with human and avian receptor analogs, respectively. These structures provide a structural basis for the different receptor-binding properties of influenza A and B virus HA molecules and for the ability of influenza B virus HA to distinguish human and avian receptors. The structure of influenza B virus HA with avian receptor analog also reveals how mutations in the region of residues 194 to 196, which are frequently observed in egg-adapted and naturally occurring variants, directly affect the receptor binding of the resultant virus strains. Furthermore, these structures of influenza B virus HA are compared with known structures of influenza A virus HAs, which suggests the role of the residue at 222 as a key and likely a universal determinant for the different binding modes of human receptor analogs by different HA molecules.

About this Structure

2RFT is a Protein complex structure of sequences from Influenza b virus. Full crystallographic information is available from OCA.

Reference

Structural basis for receptor specificity of influenza B virus hemagglutinin., Wang Q, Tian X, Chen X, Ma J, Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16874-9. Epub 2007 Oct 17. PMID:17942670 Page seeded by OCA on Sun May 4 16:50:51 2008

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