2rg8

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[[Image:2rg8.jpg|left|200px]]
[[Image:2rg8.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rg8 |SIZE=350|CAPTION= <scene name='initialview01'>2rg8</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_2rg8", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Cl+Binding+Site+For+Residue+B+2'>AC2</scene>, <scene name='pdbsite=AC3:Na+Binding+Site+For+Residue+B+3'>AC3</scene>, <scene name='pdbsite=AC4:Na+Binding+Site+For+Residue+A+4'>AC4</scene> and <scene name='pdbsite=AC5:Na+Binding+Site+For+Residue+B+5'>AC5</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= PDCD4, H731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2rg8| PDB=2rg8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [http://www.ebi.ac.uk/pdbsum/2rg8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB]</span>
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}}
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'''Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain'''
'''Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain'''
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[[Category: Suzuki, C.]]
[[Category: Suzuki, C.]]
[[Category: Wagner, G.]]
[[Category: Wagner, G.]]
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[[Category: anti-oncogene]]
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[[Category: Anti-oncogene]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: heat repeat]]
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[[Category: Heat repeat]]
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[[Category: ma3 domain]]
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[[Category: Ma3 domain]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: rna-binding]]
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[[Category: Rna-binding]]
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[[Category: translation]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:51:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:00:04 2008''
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Revision as of 13:51, 4 May 2008

Image:2rg8.jpg

Template:STRUCTURE 2rg8

Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain


Overview

Programmed Cell Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A (eIF4A), inhibit translation initiation, and act as a tumor suppressor. PDCD4 contains two C-terminal MA3 domains, which are thought to be responsible for its inhibitory function. Here, we analyze the structures and inhibitory functions of these two PDCD4 MA3 domains by x-ray crystallography, NMR, and surface plasmon resonance. We show that both MA3 domains are structurally and functionally very similar and bind specifically to the eIF4A N-terminal domain (eIF4A-NTD) using similar binding interfaces. We found that the PDCD4 MA3 domains compete with the eIF4G MA3 domain and RNA for eIF4A binding. Our data provide evidence that PDCD4 inhibits translation initiation by displacing eIF4G and RNA from eIF4A. The PDCD4 MA3 domains act synergistically to form a tighter and more stable complex with eIF4A, which explains the need for two tandem MA3 domains.

About this Structure

2RG8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains., Suzuki C, Garces RG, Edmonds KA, Hiller S, Hyberts SG, Marintchev A, Wagner G, Proc Natl Acad Sci U S A. 2008 Feb 22;. PMID:18296639 Page seeded by OCA on Sun May 4 16:51:28 2008

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