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2rgf

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[[Image:2rgf.jpg|left|200px]]
[[Image:2rgf.jpg|left|200px]]
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{{Structure
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|GENE= HUMAN RALGEF GENE (RALGDS) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2rgf| PDB=2rgf | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rgf OCA], [http://www.ebi.ac.uk/pdbsum/2rgf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rgf RCSB]</span>
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'''RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES'''
'''RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES'''
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[[Category: Kalbitzer, H R.]]
[[Category: Kalbitzer, H R.]]
[[Category: Wittinghofer, A.]]
[[Category: Wittinghofer, A.]]
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[[Category: ralgd]]
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[[Category: Ralgd]]
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[[Category: ralgef]]
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[[Category: Ralgef]]
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[[Category: ra]]
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[[Category: Ra]]
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[[Category: ras-binding domain]]
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[[Category: Ras-binding domain]]
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[[Category: rbd]]
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[[Category: Rbd]]
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Revision as of 13:52, 4 May 2008

Image:2rgf.jpg

Template:STRUCTURE 2rgf

RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES


Overview

The solution structure of the Ras-binding domain (RBD) of Ral guanine-nucleotide exchange factor RalGEF was solved by NMR spectroscopy. The overall structure is similar to that of Raf-RBD, another effector of Ras, although the sequence identity is only 13%. 15N chemical shifts changes in the complex of RalGEF-RBD with Ras indicate an interaction similar to the intermolecular beta-sheet observed for the complex between Ras and Raf-RBD.

About this Structure

2RGF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling., Geyer M, Herrmann C, Wohlgemuth S, Wittinghofer A, Kalbitzer HR, Nat Struct Biol. 1997 Sep;4(9):694-9. PMID:9302994 Page seeded by OCA on Sun May 4 16:52:11 2008

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