2rgn

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[[Image:2rgn.jpg|left|200px]]
[[Image:2rgn.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rgn |SIZE=350|CAPTION= <scene name='initialview01'>2rgn</scene>, resolution 3.500&Aring;
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The line below this paragraph, containing "STRUCTURE_2rgn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Gnaq ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), GEFT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2rgn| PDB=2rgn | SCENE= }}
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|RELATEDENTRY=[[2bcj|2bcj]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rgn OCA], [http://www.ebi.ac.uk/pdbsum/2rgn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rgn RCSB]</span>
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}}
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'''Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA'''
'''Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA'''
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[[Category: Shankaranarayanan, A.]]
[[Category: Shankaranarayanan, A.]]
[[Category: Tesmer, J J.G.]]
[[Category: Tesmer, J J.G.]]
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[[Category: adp-ribosylation]]
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[[Category: Adp-ribosylation]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: cytoskeleton]]
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[[Category: Cytoskeleton]]
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[[Category: galpha-q]]
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[[Category: Galpha-q]]
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[[Category: galphaq]]
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[[Category: Galphaq]]
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[[Category: gq]]
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[[Category: Gq]]
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[[Category: gtp-binding]]
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[[Category: Gtp-binding]]
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[[Category: heterotrimeric g-protein]]
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[[Category: Heterotrimeric g-protein]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: magnesium]]
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[[Category: Magnesium]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: methylation]]
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[[Category: Methylation]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: p63rhogef]]
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[[Category: P63rhogef]]
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[[Category: palmitate]]
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[[Category: Palmitate]]
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[[Category: prenylation]]
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[[Category: Prenylation]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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[[Category: proto-oncogene]]
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[[Category: Proto-oncogene]]
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[[Category: rhoa]]
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[[Category: Rhoa]]
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[[Category: rhogef]]
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[[Category: Rhogef]]
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[[Category: signaling complex]]
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[[Category: Signaling complex]]
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[[Category: signaling protein complex]]
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[[Category: Signaling protein complex]]
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[[Category: small molecular weight g-protein]]
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[[Category: Small molecular weight g-protein]]
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[[Category: transducer]]
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[[Category: Transducer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:52:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:00:10 2008''
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Revision as of 13:52, 4 May 2008

Image:2rgn.jpg

Template:STRUCTURE 2rgn

Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA


Overview

The guanine nucleotide exchange factor p63RhoGEF is an effector of the heterotrimeric guanine nucleotide-binding protein (G protein) Galphaq and thereby links Galphaq-coupled receptors (GPCRs) to the activation of the small-molecular-weight G protein RhoA. We determined the crystal structure of the Galphaq-p63RhoGEF-RhoA complex, detailing the interactions of Galphaq with the Dbl and pleckstrin homology (DH and PH) domains of p63RhoGEF. These interactions involve the effector-binding site and the C-terminal region of Galphaq and appear to relieve autoinhibition of the catalytic DH domain by the PH domain. Trio, Duet, and p63RhoGEF are shown to constitute a family of Galphaq effectors that appear to activate RhoA both in vitro and in intact cells. We propose that this structure represents the crux of an ancient signal transduction pathway that is expected to be important in an array of physiological processes.

About this Structure

2RGN is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs., Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ, Science. 2007 Dec 21;318(5858):1923-7. PMID:18096806 Page seeded by OCA on Sun May 4 16:52:55 2008

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