2rjd

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[[Image:2rjd.gif|left|200px]]
[[Image:2rjd.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2rjd |SIZE=350|CAPTION= <scene name='initialview01'>2rjd</scene>, resolution 1.65&Aring;
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The line below this paragraph, containing "STRUCTURE_2rjd", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2rjd| PDB=2rjd | SCENE= }}
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|RELATEDENTRY=[[2pqw|2PQW]], [[2rjc|2RJC]], [[2rje|2RJE]], [[2rjf|2RJF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjd OCA], [http://www.ebi.ac.uk/pdbsum/2rjd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rjd RCSB]</span>
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}}
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'''Crystal structure of L3MBTL1 protein'''
'''Crystal structure of L3MBTL1 protein'''
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[[Category: Vedadi, M.]]
[[Category: Vedadi, M.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: chromatin regulator]]
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[[Category: Chromatin regulator]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: l(3)mbt-like protein]]
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[[Category: Metal-binding]]
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[[Category: metal-binding]]
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[[Category: Nucleus]]
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[[Category: nucleus]]
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[[Category: Repressor]]
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[[Category: repressor]]
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[[Category: Sgc]]
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[[Category: sgc]]
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[[Category: Structural genomic]]
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[[Category: structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: structural genomics consortium]]
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[[Category: Transcription]]
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[[Category: transcription]]
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[[Category: Transcription regulation]]
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[[Category: transcription regulation]]
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[[Category: Zinc]]
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[[Category: zinc]]
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[[Category: Zinc-finger]]
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[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:01:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:01:09 2008''
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Revision as of 14:01, 4 May 2008

Image:2rjd.gif

Template:STRUCTURE 2rjd

Crystal structure of L3MBTL1 protein


Overview

Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.

About this Structure

2RJD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:18026117 Page seeded by OCA on Sun May 4 17:01:24 2008

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OCA

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