2rjf

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[[Image:2rjf.gif|left|200px]]
[[Image:2rjf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2rjf |SIZE=350|CAPTION= <scene name='initialview01'>2rjf</scene>, resolution 2.05&Aring;
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The line below this paragraph, containing "STRUCTURE_2rjf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2rjf| PDB=2rjf | SCENE= }}
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|RELATEDENTRY=[[2pqw|2PQW]], [[2rjc|2RJC]], [[2rjd|2RJD]], [[2rje|2RJE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjf OCA], [http://www.ebi.ac.uk/pdbsum/2rjf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rjf RCSB]</span>
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}}
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'''Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 12-30), orthorhombic form I'''
'''Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 12-30), orthorhombic form I'''
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[[Category: Vedadi, M.]]
[[Category: Vedadi, M.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: chromatin regulator]]
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[[Category: Chromatin regulator]]
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[[Category: chromosomal protein]]
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[[Category: Chromosomal protein]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: l(3)mbt-like protein]]
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[[Category: Metal-binding]]
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[[Category: metal-binding]]
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[[Category: Methylation]]
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[[Category: methylation]]
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[[Category: Nucleosome core]]
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[[Category: nucleosome core]]
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[[Category: Nucleus]]
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[[Category: nucleus]]
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[[Category: Repressor]]
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[[Category: repressor]]
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[[Category: Sgc]]
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[[Category: sgc]]
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[[Category: Structural genomic]]
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[[Category: structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: structural genomics consortium]]
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[[Category: Transcription]]
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[[Category: transcription]]
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[[Category: Transcription regulation]]
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[[Category: transcription regulation]]
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[[Category: Zinc]]
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[[Category: zinc]]
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[[Category: Zinc-finger]]
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[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:01:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:01:10 2008''
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Revision as of 14:01, 4 May 2008

Image:2rjf.gif

Template:STRUCTURE 2rjf

Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 12-30), orthorhombic form I


Overview

Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.

About this Structure

2RJF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:18026117 Page seeded by OCA on Sun May 4 17:01:55 2008

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OCA

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