2rjs

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[[Image:2rjs.jpg|left|200px]]
[[Image:2rjs.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2rjs |SIZE=350|CAPTION= <scene name='initialview01'>2rjs</scene>, resolution 2.400&Aring;
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The line below this paragraph, containing "STRUCTURE_2rjs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=296:(3R)-3-AMINO-2,2-DIFLUORO-3-(4-METHOXYPHENYL)PROPANOIC+ACID'>296</scene>, <scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-5-HYDROXY-4-METHYL-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= SgcC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 Streptomyces globisporus])
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-->
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|DOMAIN=
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{{STRUCTURE_2rjs| PDB=2rjs | SCENE= }}
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|RELATEDENTRY=[[2ohy|2OHY]], [[2qve|2QVE]], [[2rjr|2RJR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjs OCA], [http://www.ebi.ac.uk/pdbsum/2rjs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rjs RCSB]</span>
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}}
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'''SgTAM bound to substrate mimic'''
'''SgTAM bound to substrate mimic'''
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[[Category: Montavon, T J.]]
[[Category: Montavon, T J.]]
[[Category: 4-methylidene imidazole]]
[[Category: 4-methylidene imidazole]]
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[[Category: aminomutase]]
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[[Category: Aminomutase]]
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[[Category: c-1027]]
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[[Category: C-1027]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: mio]]
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[[Category: Mio]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:03:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:01:14 2008''
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Revision as of 14:03, 4 May 2008

Image:2rjs.jpg

Template:STRUCTURE 2rjs

SgTAM bound to substrate mimic


Overview

The synthesis and evaluation of two classes of inhibitors for SgTAM, a 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are described. A mechanism-based strategy was used to design analogs that mimic the substrate or product of the reaction and form covalent interactions with the enzyme through the MIO prosthetic group. The analogs were characterized by measuring inhibition constants and X-ray crystallographic structural analysis of the co-complexes bound to the aminomutase, SgTAM.

About this Structure

2RJS is a Single protein structure of sequence from Streptomyces globisporus. Full crystallographic information is available from OCA.

Reference

Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM., Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD, Bioorg Med Chem Lett. 2007 Nov 19;. PMID:18078753 Page seeded by OCA on Sun May 4 17:03:11 2008

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OCA

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