2rll
From Proteopedia
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[[Image:2rll.jpg|left|200px]] | [[Image:2rll.jpg|left|200px]] | ||
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| - | + | {{STRUCTURE_2rll| PDB=2rll | SCENE= }} | |
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'''CCR5 Nt(7-15)''' | '''CCR5 Nt(7-15)''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2RLL is a [[Single protein]] structure | + | 2RLL is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bewley, C A.]] | [[Category: Bewley, C A.]] | ||
[[Category: Lam, S N.]] | [[Category: Lam, S N.]] | ||
| - | [[Category: | + | [[Category: G-protein coupled receptor]] |
| - | [[Category: | + | [[Category: Glycoprotein]] |
| - | [[Category: | + | [[Category: Hiv-1 coreceptor ccr5 n-terminus bound to gp120:cd4]] |
| - | [[Category: | + | [[Category: Host-virus interaction]] |
| - | [[Category: | + | [[Category: Membrane]] |
| - | [[Category: | + | [[Category: Membrane protein]] |
| - | [[Category: | + | [[Category: Polymorphism]] |
| - | [[Category: | + | [[Category: Sulfation]] |
| - | [[Category: | + | [[Category: Transducer]] |
| - | [[Category: | + | [[Category: Transmembrane]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:08:18 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:08, 4 May 2008
CCR5 Nt(7-15)
Overview
The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d (extended loop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for understanding HIV-1 interactions with the CCR5 N terminus during viral entry and define a conserved site on gp120, whose recognition of sulfotyrosine engenders posttranslational mimicry by the immune system.
About this Structure
2RLL is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4., Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD, Science. 2007 Sep 28;317(5846):1930-4. PMID:17901336 Page seeded by OCA on Sun May 4 17:08:18 2008
