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2shp

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[[Image:2shp.gif|left|200px]]
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{{Structure
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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{{STRUCTURE_2shp| PDB=2shp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2shp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2shp OCA], [http://www.ebi.ac.uk/pdbsum/2shp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2shp RCSB]</span>
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'''TYROSINE PHOSPHATASE SHP-2'''
'''TYROSINE PHOSPHATASE SHP-2'''
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[[Category: Pluskey, S.]]
[[Category: Pluskey, S.]]
[[Category: Shoelson, S E.]]
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[[Category: insulin signaling]]
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[[Category: Insulin signaling]]
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[[Category: sh2 protein]]
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[[Category: Sh2 protein]]
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[[Category: tyrosine phosphatase]]
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[[Category: Tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:03:01 2008''
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Revision as of 14:19, 4 May 2008

Image:2shp.gif

Template:STRUCTURE 2shp

TYROSINE PHOSPHATASE SHP-2


Overview

The structure of the SHP-2 tyrosine phosphatase, determined at 2.0 angstroms resolution, shows how its catalytic activity is regulated by its two SH2 domains. In the absence of a tyrosine-phosphorylated binding partner, the N-terminal SH2 domain binds the phosphatase domain and directly blocks its active site. This interaction alters the structure of the N-SH2 domain, disrupting its phosphopeptide-binding cleft. Conversely, interaction of the N-SH2 domain with phosphopeptide disrupts its phosphatase recognition surface. Thus, the N-SH2 domain is a conformational switch; it either binds and inhibits the phosphatase, or it binds phosphoproteins and activates the enzyme. Recognition of bisphosphorylated ligands by the tandem SH2 domains is an integral element of this switch; the C-terminal SH2 domain contributes binding energy and specificity, but it does not have a direct role in activation.

About this Structure

2SHP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tyrosine phosphatase SHP-2., Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE, Cell. 1998 Feb 20;92(4):441-50. PMID:9491886 Page seeded by OCA on Sun May 4 17:19:04 2008

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