2spt

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[[Image:2spt.jpg|left|200px]]
[[Image:2spt.jpg|left|200px]]
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{{Structure
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|PDB= 2spt |SIZE=350|CAPTION= <scene name='initialview01'>2spt</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2spt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2spt| PDB=2spt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2spt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2spt OCA], [http://www.ebi.ac.uk/pdbsum/2spt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2spt RCSB]</span>
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}}
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'''DIFFERENCES IN THE METAL ION STRUCTURE BETWEEN SR-AND CA-PROTHROMBIN FRAGMENT 1'''
'''DIFFERENCES IN THE METAL ION STRUCTURE BETWEEN SR-AND CA-PROTHROMBIN FRAGMENT 1'''
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[[Category: Thrombin]]
[[Category: Thrombin]]
[[Category: Tulinsky, A.]]
[[Category: Tulinsky, A.]]
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[[Category: hydrolase(serine proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:21:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:03:22 2008''
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Revision as of 14:21, 4 May 2008

Image:2spt.jpg

Template:STRUCTURE 2spt

DIFFERENCES IN THE METAL ION STRUCTURE BETWEEN SR-AND CA-PROTHROMBIN FRAGMENT 1


Overview

The structure of Sr-prothrombin fragment 1 has been solved and refined by restrained least-squares methods at 2.5-A resolution to a crystallographic R value of 0.167. The protein structure is very similar to that of Ca-fragment 1. A polymeric array of five Sr2+ ions separated by about 4.0 A is buried among six gamma-carboxyglutamic acid (Gla) residues; three other Sr2+ ions interact with other Gla residues and are located further apart. One of these was not found in the Ca-fragment 1 structure. The coordination of the Sr2+ ions resembles that of Ca2+, but there are some significant differences between them. The most notable is the lack of water coordination with Sr2+ ions and two conformations for Gla 8, which change the coordination of Sr-2 and Sr-3. A hexose moiety of an oligosaccharide was located in the vicinity of Asn101 that was flexibly disordered in Ca-fragment 1. The new Sr2+ ion found may be involved in metal ion phospholipid binding interactions along with Sr-1, and Sr-7, Sr-8.

About this Structure

2SPT is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Differences in the metal ion structure between Sr- and Ca-prothrombin fragment 1., Seshadri TP, Skrzypczak-Jankun E, Yin M, Tulinsky A, Biochemistry. 1994 Feb 8;33(5):1087-92. PMID:8110739 Page seeded by OCA on Sun May 4 17:21:12 2008

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