2src

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[[Image:2src.gif|left|200px]]
[[Image:2src.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2src |SIZE=350|CAPTION= <scene name='initialview01'>2src</scene>, resolution 1.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2src", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2src| PDB=2src | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2src FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2src OCA], [http://www.ebi.ac.uk/pdbsum/2src PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2src RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP'''
'''CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP'''
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[[Category: Lei, M.]]
[[Category: Lei, M.]]
[[Category: Xu, W.]]
[[Category: Xu, W.]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: phosphotransferase]]
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[[Category: Phosphotransferase]]
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[[Category: phosphotyrosine]]
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[[Category: Phosphotyrosine]]
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[[Category: proto-oncogene]]
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[[Category: Proto-oncogene]]
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[[Category: sh2]]
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[[Category: Sh2]]
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[[Category: sh3]]
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[[Category: Sh3]]
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[[Category: src]]
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[[Category: Src]]
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[[Category: tyrosine-protein kinase]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:21:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:03:26 2008''
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Revision as of 14:21, 4 May 2008

Image:2src.gif

Template:STRUCTURE 2src

CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP


Overview

Src family kinases are maintained in an assembled, inactive conformation by intramolecular interactions of their SH2 and SH3 domains. Full catalytic activity requires release of these restraints as well as phosphorylation of Tyr-416 in the activation loop. In previous structures of inactive Src kinases, Tyr-416 and flanking residues are disordered. We report here four additional c-Src structures in which this segment adopts an ordered but inhibitory conformation. The ordered activation loop forms an alpha helix that stabilizes the inactive conformation of the kinase domain, blocks the peptide substrate-binding site, and prevents Tyr-416 phosphorylation. Disassembly of the regulatory domains, induced by SH2 or SH3 ligands, or by dephosphorylation of Tyr-527, could lead to exposure and phosphorylation of Tyr-416.

About this Structure

2SRC is a Single protein structure of sequence from Homo sapiens. The following pages contain interesting information on the relation of 2SRC with [Ubiquitin]. Full crystallographic information is available from OCA.

Reference

Crystal structures of c-Src reveal features of its autoinhibitory mechanism., Xu W, Doshi A, Lei M, Eck MJ, Harrison SC, Mol Cell. 1999 May;3(5):629-38. PMID:10360179 Page seeded by OCA on Sun May 4 17:21:19 2008

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