1a0t
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(New page: 200px<br /><applet load="1a0t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a0t, resolution 2.4Å" /> '''SUCROSE-SPECIFIC PORI...)
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Revision as of 08:25, 20 November 2007
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SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES
Overview
The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella, typhimurium has been determined by multiple isomorphous replacement at 2.4, A resolution both in its uncomplexed form and with bound sucrose. ScrY is, a noncrystallographic trimer of identical subunits, each with 413, structurally well-defined amino acids. A monomer is built up of 18, anti-parallel beta-strands surrounding a hydrophilic pore, with a topology, closely similar to that of maltoporin. Two non-overlapping sucrose-binding, sites were identified in difference Fourier maps. The higher permeability, for sucrose of ScrY as compared to maltoporin is mainly accounted for by, differences in their pore-lining residues.
About this Structure
1A0T is a Single protein structure of sequence from Salmonella typhimurium with SUC and CA as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose., Forst D, Welte W, Wacker T, Diederichs K, Nat Struct Biol. 1998 Jan;5(1):37-46. PMID:9437428
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