2tio

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[[Image:2tio.jpg|left|200px]]
[[Image:2tio.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2tio |SIZE=350|CAPTION= <scene name='initialview01'>2tio</scene>, resolution 1.93&Aring;
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The line below this paragraph, containing "STRUCTURE_2tio", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2tio| PDB=2tio | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2tio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tio OCA], [http://www.ebi.ac.uk/pdbsum/2tio PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2tio RCSB]</span>
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}}
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'''LOW PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE'''
'''LOW PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE'''
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[[Category: Tang, Q.]]
[[Category: Tang, Q.]]
[[Category: Zhu, G.]]
[[Category: Zhu, G.]]
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[[Category: benzamidine inhibited]]
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[[Category: Benzamidine inhibited]]
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[[Category: cyclohexane]]
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[[Category: Cyclohexane]]
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[[Category: hydrolase (serine proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:24:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:03:43 2008''
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Revision as of 14:24, 4 May 2008

Image:2tio.jpg

Template:STRUCTURE 2tio

LOW PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE


Overview

Two orthorhombic forms (Vm values are 2.3 and 3.0 A3/Da) of bovine beta-trypsin crystals in neat cyclohexane were determined to 1.93 A resolution, by X-ray diffraction. Both structures in organic solvent are similar to those in aqueous solution. In the high packing density form, one cyclohexane molecule is found in a hydrophobic site near the active center. One sulfate locates at the active site with hydrogen or salt bond to the Ser-His catalytic diad, and five more sulfates bind on the molecular surface. The conformation of the side chains near the sulfates changed greatly. In the low packing density form, one cyclohexane and three sulfates are found. In both structures, one benzamidine molecule locates at the hydrophobic pocket of the active center. Most water molecules on the enzyme surface are retained except some with high temperature factors.

About this Structure

2TIO is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

X-ray studies on two forms of bovine beta-trypsin crystals in neat cyclohexane., Zhu G, Huang Q, Wang Z, Qian M, Jia Y, Tang Y, Biochim Biophys Acta. 1998 Dec 8;1429(1):142-50. PMID:9920392 Page seeded by OCA on Sun May 4 17:24:11 2008

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