2trc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2trc.gif|left|200px]]
[[Image:2trc.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2trc |SIZE=350|CAPTION= <scene name='initialview01'>2trc</scene>, resolution 2.4&Aring;
+
The line below this paragraph, containing "STRUCTURE_2trc", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2trc| PDB=2trc | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2trc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2trc OCA], [http://www.ebi.ac.uk/pdbsum/2trc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2trc RCSB]</span>
+
-
}}
+
'''PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX'''
'''PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX'''
Line 29: Line 26:
[[Category: Gaudet, R.]]
[[Category: Gaudet, R.]]
[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
-
[[Category: beta-gamma]]
+
[[Category: Beta-gamma]]
-
[[Category: complex (transducer/transduction)]]
+
[[Category: G protein]]
-
[[Category: g protein]]
+
[[Category: Meka]]
-
[[Category: meka]]
+
[[Category: Phosducin]]
-
[[Category: phosducin]]
+
[[Category: Phosphorylation]]
-
[[Category: phosphorylation]]
+
[[Category: Regulation]]
-
[[Category: regulation]]
+
[[Category: Signal transduction]]
-
[[Category: signal transduction]]
+
[[Category: Thioredoxin]]
-
[[Category: thioredoxin]]
+
[[Category: Transducin]]
-
[[Category: transducin]]
+
[[Category: Vision]]
-
[[Category: vision]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:26:08 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:04:04 2008''
+

Revision as of 14:26, 4 May 2008

Image:2trc.gif

Template:STRUCTURE 2trc

PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX


Overview

The crystal structure of transducin's betagamma subunits complexed with phosducin, which regulates Gtbetagamma activity, has been solved to 2.4 angstroms resolution. Phosducin has two domains that wrap around Gtbetagamma to form an extensive interface. The N-terminal domain binds loops on the "top" Gtbeta surface, overlapping the Gtalpha binding surface, explaining how phosducin blocks Gtbetagamma's interaction with Gtalpha. The C-terminal domain shows structural homology to thioredoxin and binds the outer strands of Gtbeta's seventh and first blades in a manner likely to disrupt Gtbetagamma's normal orientation relative to the membrane and receptor. Phosducin's Ser-73, which when phosphorylated inhibits phosducin's function, points away from Gtbetagamma, toward a large flexible loop. Thus phosphorylation is not likely to affect the interface directly, but rather indirectly through an induced conformational change.

About this Structure

2TRC is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin., Gaudet R, Bohm A, Sigler PB, Cell. 1996 Nov 1;87(3):577-88. PMID:8898209 Page seeded by OCA on Sun May 4 17:26:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2trc"
Personal tools