1a1d
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(New page: 200px<br /><applet load="1a1d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a1d" /> '''YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINI...)
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Revision as of 08:25, 20 November 2007
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YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINIMIZED AVERAGE STRUCTURE, ALPHA CARBONS ONLY
Overview
RNA polymerase II subunit RPB8 is an essential subunit that is highly, conserved throughout eukaryotic evolution and is present in all three, types of nuclear RNA polymerases. We report the first high resolution, structural insight into eukaryotic RNA polymerase architecture with the, solution structure of RPB8 from Saccharomyces cerevisiae. It consists of, an eight stranded, antiparallel beta-barrel, four short helical regions, and a large, unstructured omega-loop. The strands are connected in classic, Greek-key fashion. The overall topology is unusual and contains a striking, C2 rotational symmetry. Furthermore, it is most likely a novel associate, of the oligonucleotide/oligosaccharide (OB) binding protein class.
About this Structure
1A1D is a Single protein structure of sequence from Saccharomyces cerevisiae. Active as DNA-directed RNA polymerase, with EC number 2.7.7.6 Full crystallographic information is available from OCA.
Reference
Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family., Krapp S, Kelly G, Reischl J, Weinzierl RO, Matthews S, Nat Struct Biol. 1998 Feb;5(2):110-4. PMID:9461075
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