2ukd

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[[Image:2ukd.gif|left|200px]]
[[Image:2ukd.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ukd |SIZE=350|CAPTION= <scene name='initialview01'>2ukd</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2ukd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=C5P:CYTIDINE-5&#39;-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytidylate_kinase Cytidylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.14 2.7.4.14] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= KCY_DICDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum])
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-->
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|DOMAIN=
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{{STRUCTURE_2ukd| PDB=2ukd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ukd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ukd OCA], [http://www.ebi.ac.uk/pdbsum/2ukd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ukd RCSB]</span>
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}}
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'''UMP/CMP KINASE FROM SLIME MOLD COMPLEXED WITH ADP, CMP'''
'''UMP/CMP KINASE FROM SLIME MOLD COMPLEXED WITH ADP, CMP'''
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[[Category: Reinstein, J.]]
[[Category: Reinstein, J.]]
[[Category: Schlichting, I.]]
[[Category: Schlichting, I.]]
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[[Category: nmp kinase]]
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[[Category: Nmp kinase]]
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[[Category: nucleoside monophosphate kinase]]
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[[Category: Nucleoside monophosphate kinase]]
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[[Category: phosphoryl transfer]]
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[[Category: Phosphoryl transfer]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:28:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:04:25 2008''
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Revision as of 14:28, 4 May 2008

Image:2ukd.gif

Template:STRUCTURE 2ukd

UMP/CMP KINASE FROM SLIME MOLD COMPLEXED WITH ADP, CMP


Overview

UMP/CMP kinase from Dictyostelium discoideum (UmpKdicty) catalyzes the specific transfer of the terminal phosphate of ATP to UMP or CMP. Crystal structures of UmpKdicty with substrates and the transition state analogs AlF3 or BeF2 that lock UmpKdicty in active conformations were solved. The positions of the catalytic Mg2+ and the highly conserved lysine of the P loop are virtually invariant in the different structures. In contrast, catalytic arginines move to stabilize charges that develop during this reaction. The location of the arginines indicates formation of negative charges during the reaction at the transferred phosphoryl group, but not at the phosphate bridging oxygen atoms. This is consistent with an associative phosphoryl transfer mechanism but not with a dissociative one.

About this Structure

2UKD is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative., Schlichting I, Reinstein J, Biochemistry. 1997 Aug 5;36(31):9290-6. PMID:9280438 Page seeded by OCA on Sun May 4 17:28:31 2008

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