2uy1

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy1 OCA], [http://www.ebi.ac.uk/pdbsum/2uy1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uy1 RCSB]</span>
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'''CRYSTAL STRUCTURE OF CSTF-77'''
'''CRYSTAL STRUCTURE OF CSTF-77'''
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[[Category: Minvielle-Sebastia, L.]]
[[Category: Minvielle-Sebastia, L.]]
[[Category: Pinaud, N.]]
[[Category: Pinaud, N.]]
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[[Category: rna-binding protein]]
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[[Category: Rna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:46:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:07 2008''
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Revision as of 14:46, 4 May 2008

Image:2uy1.jpg

Template:STRUCTURE 2uy1

CRYSTAL STRUCTURE OF CSTF-77


Overview

The cleavage stimulation factor (CstF) is essential for the first step of poly(A) tail formation at the 3' ends of mRNAs. This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the crystal structure of the 77-kDa protein from Encephalitozoon cuniculi at a resolution of 2 A. The structure folds around 11 Half-a-TPR repeats defining two domains. The crystal structure reveals a tight homodimer exposing phylogenetically conserved areas for interaction with protein partners. Mapping experiments identify the C-terminal region of Rna14p, the yeast counterpart of CstF-77, as the docking domain for Rna15p, the yeast CstF-64 homologue.

About this Structure

2UY1 is a Single protein structure of sequence from Encephalitozoon cuniculi. Full crystallographic information is available from OCA.

Reference

The structure of the CstF-77 homodimer provides insights into CstF assembly., Legrand P, Pinaud N, Minvielle-Sebastia L, Fribourg S, Nucleic Acids Res. 2007;35(13):4515-22. Epub 2007 Jun 21. PMID:17584787 Page seeded by OCA on Sun May 4 17:46:54 2008

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