2uym

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[[Image:2uym.gif|left|200px]]
[[Image:2uym.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2uym |SIZE=350|CAPTION= <scene name='initialview01'>2uym</scene>, resolution 2.11&Aring;
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The line below this paragraph, containing "STRUCTURE_2uym", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:K03+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K03:N,N-DIETHYL-5,5-DIMETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE'>K03</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2uym| PDB=2uym | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uym OCA], [http://www.ebi.ac.uk/pdbsum/2uym PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uym RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37'''
'''CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Lee, T T.]]
[[Category: Lee, T T.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: eg5]]
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[[Category: Eg5]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: kinesin spindle protein]]
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[[Category: Kinesin spindle protein]]
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[[Category: ksp]]
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[[Category: Ksp]]
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[[Category: microtubule]]
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[[Category: Microtubule]]
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[[Category: mitosis]]
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[[Category: Mitosis]]
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[[Category: motor protein]]
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[[Category: Motor protein]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: thiophene]]
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[[Category: Thiophene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:49:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:18 2008''
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Revision as of 14:49, 4 May 2008

Image:2uym.gif

Template:STRUCTURE 2uym

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37


Overview

We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.

About this Structure

2UYM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors., Pinkerton AB, Lee TT, Hoffman TZ, Wang Y, Kahraman M, Cook TG, Severance D, Gahman TC, Noble SA, Shiau AK, Davis RL, Bioorg Med Chem Lett. 2007 Jul 1;17(13):3562-9. Epub 2007 Apr 29. PMID:17498954 Page seeded by OCA on Sun May 4 17:49:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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