2uyt

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[[Image:2uyt.gif|left|200px]]
[[Image:2uyt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2uyt |SIZE=350|CAPTION= <scene name='initialview01'>2uyt</scene>, resolution 1.55&Aring;
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The line below this paragraph, containing "STRUCTURE_2uyt", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=LRH:6-DEOXY-BETA-L-FRUCTOFURANOSE'>LRH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhamnulokinase Rhamnulokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.5 2.7.1.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2uyt| PDB=2uyt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uyt OCA], [http://www.ebi.ac.uk/pdbsum/2uyt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uyt RCSB]</span>
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}}
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'''STRUCTURE OF L-RHAMNULOSE KINASE IN COMPLEX WITH ADP AND BETA-L-RHAMNULOSE.'''
'''STRUCTURE OF L-RHAMNULOSE KINASE IN COMPLEX WITH ADP AND BETA-L-RHAMNULOSE.'''
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[[Category: Grueninger, D.]]
[[Category: Grueninger, D.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
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[[Category: hexokinase-hsp70- actin superfamily]]
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[[Category: Hexokinase-hsp70- actin superfamily]]
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[[Category: in-line phosphoryl transfer]]
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[[Category: In-line phosphoryl transfer]]
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[[Category: induced fit]]
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[[Category: Induced fit]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: l-rhamnulose kinase]]
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[[Category: L-rhamnulose kinase]]
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[[Category: rare sugar]]
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[[Category: Rare sugar]]
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[[Category: rhamnose degradation]]
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[[Category: Rhamnose degradation]]
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[[Category: rhamnose metabolism]]
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[[Category: Rhamnose metabolism]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:49:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:25 2008''
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Revision as of 14:49, 4 May 2008

Image:2uyt.gif

Template:STRUCTURE 2uyt

STRUCTURE OF L-RHAMNULOSE KINASE IN COMPLEX WITH ADP AND BETA-L-RHAMNULOSE.


Overview

The enzyme L-rhamnulose kinase from Escherichia coli participates in the degradation pathway of L-rhamnose, a common natural deoxy-hexose. The structure of the enzyme in a ternary complex with its substrates ADP and L-rhamnulose has been determined at 1.55A resolution and refined to R(cryst)/R(free) values of 0.179/0.209. The result was compared with the lower resolution structure of a corresponding complex containing L-fructose instead of L-rhamnulose. In light of the two established sugar positions and conformations, a number of rare sugars have been modeled into the active center of L-rhamnulose kinase and the model structures have been compared with the known enzymatic phosphorylation rates. Rare sugars are of rising interest for the synthesis of bioactive compounds.

About this Structure

2UYT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Substrate spectrum of L-rhamnulose kinase related to models derived from two ternary complex structures., Grueninger D, Schulz GE, FEBS Lett. 2007 Jun 26;581(16):3127-30. Epub 2007 Jun 6. PMID:17568582 Page seeded by OCA on Sun May 4 17:49:56 2008

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