2uz1

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[[Image:2uz1.gif|left|200px]]
[[Image:2uz1.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2uz1 |SIZE=350|CAPTION= <scene name='initialview01'>2uz1</scene>, resolution 1.65&Aring;
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The line below this paragraph, containing "STRUCTURE_2uz1", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mpd+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Benzoin_aldolase Benzoin aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.38 4.1.2.38] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2uz1| PDB=2uz1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz1 OCA], [http://www.ebi.ac.uk/pdbsum/2uz1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uz1 RCSB]</span>
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}}
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'''1.65 ANGSTROM STRUCTURE OF BENZALDEHYDE LYASE COMPLEXED WITH 2-METHYL-2,4-PENTANEDIOL'''
'''1.65 ANGSTROM STRUCTURE OF BENZALDEHYDE LYASE COMPLEXED WITH 2-METHYL-2,4-PENTANEDIOL'''
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[[Category: Maraite, A.]]
[[Category: Maraite, A.]]
[[Category: Schmidt, T.]]
[[Category: Schmidt, T.]]
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[[Category: benzaldehyde]]
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[[Category: Benzaldehyde]]
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[[Category: benzoin]]
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[[Category: Benzoin]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: thiamine diphosphate]]
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[[Category: Thiamine diphosphate]]
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[[Category: thiamine pyrophosphate]]
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[[Category: Thiamine pyrophosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:50:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:29 2008''
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Revision as of 14:50, 4 May 2008

Image:2uz1.gif

Template:STRUCTURE 2uz1

1.65 ANGSTROM STRUCTURE OF BENZALDEHYDE LYASE COMPLEXED WITH 2-METHYL-2,4-PENTANEDIOL


Overview

Benzaldehyde lyase (BAL; EC 4.1.2.38) is a thiamine diphosphate (ThDP) dependent enzyme that catalyses the enantioselective carboligation of two molecules of benzaldehyde to form (R)-benzoin. BAL has hence aroused interest for its potential in the industrial synthesis of optically active benzoins and derivatives. The structure of BAL was previously solved to a resolution of 2.6 A using MAD experiments on a selenomethionine derivative [Mosbacher et al. (2005), FEBS J. 272, 6067-6076]. In this communication of parallel studies, BAL was crystallized in an alternative space group (P2(1)2(1)2(1)) and its structure refined to a resolution of 1.65 A, allowing detailed observation of the water structure, active-site interactions with ThDP and also the electron density for the co-solvent 2-methyl-2,4-pentanediol (MPD) at hydrophobic patches of the enzyme surface.

About this Structure

2UZ1 is a Single protein structure of sequence from Pseudomonas fluorescens. Full crystallographic information is available from OCA.

Reference

Structure of the ThDP-dependent enzyme benzaldehyde lyase refined to 1.65 A resolution., Maraite A, Schmidt T, Ansorge-Schumacher MB, Brzozowski AM, Grogan G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jul 1;63(Pt, 7):546-8. Epub 2007 Jun 15. PMID:17620706 Page seeded by OCA on Sun May 4 17:50:48 2008

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