2v0e

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[[Image:2v0e.gif|left|200px]]
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{{Structure
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{{STRUCTURE_2v0e| PDB=2v0e | SCENE= }}
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|RELATEDENTRY=[[2ckc|2CKC]], [[2v0f|2V0F]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0e OCA], [http://www.ebi.ac.uk/pdbsum/2v0e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v0e RCSB]</span>
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'''BRK DOMAIN FROM HUMAN CHD7'''
'''BRK DOMAIN FROM HUMAN CHD7'''
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[[Category: Freund, S M.V.]]
[[Category: Freund, S M.V.]]
[[Category: Religa, T L.]]
[[Category: Religa, T L.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: brk domain]]
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[[Category: Brk domain]]
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[[Category: charge syndrome]]
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[[Category: Charge syndrome]]
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[[Category: chd7]]
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[[Category: Chd7]]
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[[Category: chromatin regulator]]
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[[Category: Chromatin regulator]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: helicase]]
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[[Category: Helicase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:57:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:58 2008''
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Revision as of 14:57, 4 May 2008

Image:2v0e.gif

Template:STRUCTURE 2v0e

BRK DOMAIN FROM HUMAN CHD7


Overview

CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.

About this Structure

2V0E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the BRK domains from CHD7., Allen MD, Religa TL, Freund SM, Bycroft M, J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9. PMID:17603073 Page seeded by OCA on Sun May 4 17:57:22 2008

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