2v0o

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{{Structure
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The line below this paragraph, containing "STRUCTURE_2v0o", creates the "Structure Box" on the page.
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0o OCA], [http://www.ebi.ac.uk/pdbsum/2v0o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v0o RCSB]</span>
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'''FCHO2 F-BAR DOMAIN'''
'''FCHO2 F-BAR DOMAIN'''
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[[Category: Kent, H M.]]
[[Category: Kent, H M.]]
[[Category: Mcmahon, H T.]]
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[[Category: coiled-coil]]
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[[Category: Coiled-coil]]
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[[Category: efc domain]]
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[[Category: Efc domain]]
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[[Category: endocytosis]]
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[[Category: Exocytosis]]
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[[Category: f-bar domain]]
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[[Category: F-bar domain]]
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[[Category: lipid-binding protein]]
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[[Category: Lipid-binding protein]]
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[[Category: membrane curvature]]
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[[Category: Membrane curvature]]
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[[Category: Polymorphism]]
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[[Category: vesicle trafficking]]
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[[Category: Vesicle trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:58:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:07:04 2008''
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Revision as of 14:58, 4 May 2008

Image:2v0o.gif

Template:STRUCTURE 2v0o

FCHO2 F-BAR DOMAIN


Overview

A spectrum of membrane curvatures exists within cells, and proteins have evolved different modules to detect, create, and maintain these curvatures. Here we present the crystal structure of one such module found within human FCHo2. This F-BAR (extended FCH) module consists of two F-BAR domains, forming an intrinsically curved all-helical antiparallel dimer with a Kd of 2.5 microM. The module binds liposomes via a concave face, deforming them into tubules with variable diameters of up to 130 nm. Pulse EPR studies showed the membrane-bound dimer is the same as the crystal dimer, although the N-terminal helix changed conformation on membrane binding. Mutation of a phenylalanine on this helix partially attenuated narrow tubule formation, and resulted in a gain of curvature sensitivity. This structure shows a distant relationship to curvature-sensing BAR modules, and suggests how similar coiled-coil architectures in the BAR superfamily have evolved to expand the repertoire of membrane-sculpting possibilities.

About this Structure

2V0O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature., Henne WM, Kent HM, Ford MG, Hegde BG, Daumke O, Butler PJ, Mittal R, Langen R, Evans PR, McMahon HT, Structure. 2007 Jul;15(7):839-52. Epub 2007 Jun 1. PMID:17540576 Page seeded by OCA on Sun May 4 17:58:56 2008

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