2v1u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2v1u.gif|left|200px]]
[[Image:2v1u.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2v1u |SIZE=350|CAPTION= <scene name='initialview01'>2v1u</scene>, resolution 3.10&Aring;
+
The line below this paragraph, containing "STRUCTURE_2v1u", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+A'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2v1u| PDB=2v1u | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v1u OCA], [http://www.ebi.ac.uk/pdbsum/2v1u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v1u RCSB]</span>
+
-
}}
+
'''STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA'''
'''STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA'''
Line 29: Line 26:
[[Category: Westcott, S L.]]
[[Category: Westcott, S L.]]
[[Category: Wigley, D B.]]
[[Category: Wigley, D B.]]
-
[[Category: archaea]]
+
[[Category: Archaea]]
-
[[Category: atp-binding]]
+
[[Category: Atp-binding]]
-
[[Category: dna replication]]
+
[[Category: Dna replication]]
-
[[Category: dna replication initiation]]
+
[[Category: Dna replication initiation]]
-
[[Category: nucleotide-binding]]
+
[[Category: Nucleotide-binding]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: replication]]
+
[[Category: Replication]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:03:12 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:07:32 2008''
+

Revision as of 15:03, 4 May 2008

Image:2v1u.gif

Template:STRUCTURE 2v1u

STRUCTURE OF THE AEROPYRUM PERNIX ORC1 PROTEIN IN COMPLEX WITH DNA


Overview

DNA replication in archaea and in eukaryotes share many similarities. We report the structure of an archaeal origin recognition complex protein, ORC1, bound to an origin recognition box, a DNA sequence that is found in multiple copies at replication origins. DNA binding is mediated principally by a C-terminal winged helix domain that inserts deeply into the major and minor grooves, widening them both. However, additional DNA contacts are made with the N-terminal AAA+ domain, which inserts into the minor groove at a characteristic G-rich sequence, inducing a 35 degrees bend in the duplex and providing directionality to the binding site. Both contact regions also induce substantial unwinding of the DNA. The structure provides insight into the initial step in assembly of a replication origin and recruitment of minichromosome maintenance (MCM) helicase to that origin.

About this Structure

2V1U is a Protein complex structure of sequences from Aeropyrum pernix. Full crystallographic information is available from OCA.

Reference

Structural basis of DNA replication origin recognition by an ORC protein., Gaudier M, Schuwirth BS, Westcott SL, Wigley DB, Science. 2007 Aug 31;317(5842):1213-6. PMID:17761880 Page seeded by OCA on Sun May 4 18:03:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v1u"
Personal tools